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International Journal of Dermatology

International Journal of Dermatology

IF: 3.5
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OCCUPATIONAL ALLERGIC CONTACT DERMATITIS CAUSED BY 2,4,6-TRIS-(DIMETHYLAMINOMETHYL)PHENOL, AND REVIEW OF SENSITIZING EPOXY RESIN HARDENERS

Published:1 December 1996 DOI: 10.1111/j.1365-4362.1996.tb05050.x PMID: 8970840
LASSE KANEKRVA M.D., Ph.D., TUULA ESTLANDER M.D., Ph.D., RIITTA JOLANKI D.tech

Abstract

Background. Epoxy resin compounds (ERG) include a large number of sensitizing chemicals such as epoxy resins (ER), hardeners (curing agents), and reactive diluents. Allergic contact dermatitis (ACD) caused by ERCS is often occupational.

Materials and Methods. We report a patient, sensitized to a hardener of a two-component epoxy paint. Three conventional patch test sessions were performed to diagnose the causative chemical. We also review the literature on sensitizing epoxy-resin hardeners.

Results. A 47-year-old nonatopic woman developed dermatitis from a two-component epoxy paint. Patch testing with epoxy resin was negative, but 2,4,6–tris(dimethylaminomethyl)phenol (tris-DMP), used in the paint hardener, induced an allergic patch test reaction. We also review briefly other epoxy hardeners that have caused allergic dermatitis, including: (1) aliphatic polyamines, e.g., ethylenediamine, diethylenetriamine, triethylenetetramine, 3-dimethylaminopropylamine, and trimethylhexamethylenediamine; (2) cycloaliphatic polyamines, e.g., isophoronediamine and 3,3′-dimethyl-4,4-diaminodicyclohexylmethane; (3) aromatic amines, such as 4,4′-diaminodiphenylmethane, m-phenylene diamine, and 1,3-xylylene diamine; (4) dicyanodiamide; (5) triglycidyl isocyanurate, an epoxy compound that may be used as an epoxy-resin hardener; and (6) additives in epoxy accelerators, such as hexavalent chromate.

Conclusions. No one chemical can be used to screen for sensitization to the many different epoxy hardeners. Extensive patch testing may be required to reveal the hardener that has caused the allergy. The hardener, 2,4,6-tris-dimethylaminomethyDphenol (tris-DMP), is a new sensitizer. To verify ACD caused by tris-DMP, patch-testing at 1% in petrolatum is suggested.

Substances (17)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Dicyandiamide 461-58-5 C2H4N4 856 suppliers $6.00-$1380.00
Diethylenetriamine 111-40-0 C4H13N3 550 suppliers $13.44-$1051.86
m-Phenylenediamine 108-45-2 C6H8N2 504 suppliers $13.00-$4478.20
Triethylenetetramine 112-24-3 C6H18N4 454 suppliers $13.44-$4277.25
4,4'-Methylenedianiline 101-77-9 C13H14N2 404 suppliers $15.00-$1559.25
3-Dimethylaminopropylamine 109-55-7 C5H14N2 394 suppliers $16.00-$3418.80
1,3-Bis(aminomethyl)benzene 1477-55-0 C8H12N2 393 suppliers $10.00-$4338.74
1,3,5-Triglycidyl isocyanurate 2451-62-9 C12H15N3O6 375 suppliers $30.00-$360.00
Tris(dimethylaminomethyl)phenol 90-72-2 C15H27N3O 363 suppliers $6.00-$912.29
Isophorondiamine 2855-13-2 C10H22N2 258 suppliers $14.00-$2148.30

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