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Phytomedicine

Phytomedicine

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Asiaticoside alleviated NAFLD by activating Nrf2 and inhibiting the NF-κB pathway

Published:5 December 2024 DOI: 10.1016/j.phymed.2024.156317 PMID: 39667137
Yunfei Wei,?Yibo Zhang,?Baihe Zhan,?Yajie Wang,?Jiaqi Cheng,?Hao Yu,?Mengfan Lv,?Yanmin Zhang,?Yaxin Zhai,?Yuan Guan,?Haihua Feng

Abstract

Background: Nonalcoholic fatty liver disease (NAFLD) is a globally prevalent clinical problem of chronic liver disorder whose main pathogenic mechanisms are hepatic lipid accumulation, oxidative stress, and inflammatory reactions. Asiaticoside (Asi) is a compound derived from Centella asiatica, possesses antioxidant, antiphlogistic, antifibrotic, as well as wound healing properties.

Purpose: The aim of this study was to investigate the effects of Asi on NAFLD and its potential mechanisms.

Study design: Two versions of experimental models were constructed using free fatty acids (FFAs)-stimulated HepG2 cells along with high-fat diet (HFD)-incited NAFLD in mice.

Methods: The pivotal action of Nrf2 was then explored using Ml-385 or Nrf2-/- mice.

Results: The results indicated that Asi activated the Nrf2 to alleviate oxidative stress, inhibited the NF-κB to reduce the inflammatory response, and notably decreased lipid droplets and alleviated steatosis.

Conclusion: In conclusion, Asi demonstrates a potential to activate Nrf2 as well as inhibit the NF-κB pathway, there alleviate NAFLD.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Glutathione 70-18-8 C10H17N3O6S 1134 suppliers $6.00-$3420.00
Hematoxylin 517-28-2 C16H14O6 438 suppliers $5.00-$6710.00
Nile Red 7385-67-3 C20H18N2O2 260 suppliers $38.00-$862.40
DAPI 47165-04-8 C16H15N5 13 suppliers $504.53-$504.53