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Journal of Controlled Release

Journal of Controlled Release

IF: 10.5
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Curcumin-release antibacterial dressings with antioxidation and anti-inflammatory function for diabetic wound healing and glucose monitoring

Published:12 December 2024 DOI: 10.1016/j.jconrel.2024.12.012
Xiao Wang, Haoling Huo, Lin Cao, Yanming Zhong, Jin Gong, Zhidan Lin, Xiaobao Xie, Zhen Bao, Peng Zhang

Abstract

Diabetic wound healing remains a challenge due to high levels of oxidative stress, excessive inflammation, and bacterial infection. Smart dressings loaded with natural active monomers are proving to be effective strategies for enhancing diabetic wound healing. Herein, the bio-composites (PTIGA-Cur and PTIGA-Cur-Ag) with curcumin (Cur) responsive release were reported for promoting angiogenesis and diabetic wound repair, showing excellent anti-inflammatory, antioxidant, and antibacterial properties. The integration of three-dimensional networks and chemical bonds endowed the bio-composites with superior thermodynamic, mechanical, and self-healing properties. Notably, pH-responsive Schiff base as well as ester groups in the matrix enable the Cur to be released in a controlled manner. A biosensor assembled from PTIGA-Cur-Ag demonstrated electronic conductivity based on in-situ synthesis of AgNPs, which enabled sensitive monitoring of blood glucose levels. In addition, the release of AgNPs enhanced the antibacterial and anti-inflammatory properties. Expectedly, the bio-composites exhibited remarkable biocompatibility, effectively promoting the polarization of macrophages to M2 phenotype, and reducing the expression of proinflammatory cytokines. The full-thickness diabetic wound model revealed that PTIGA-Cur and PTIGA-Cur-Ag were able to effectively promote collagen deposition, neovascularization, and granulation tissue regeneration through their anti-inflammatory, antioxidant, and antibacterial properties. This study provides evidence supporting the potential utility of bio-composites with both pro-healing properties and monitoring functions in the management of diabetic wounds.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
D(+)-Glucose 50-99-7 C6H12O6 1113 suppliers $6.00-$26950.00
Tetrahydrofuran 109-99-9 C4H8O 1102 suppliers $9.00-$17160.00
Streptozotocin 18883-66-4 C8H15N3O7 428 suppliers $25.00-$1610.00
3-Aminobenzeneboronic acid 30418-59-8 C6H8BNO2 286 suppliers $6.00-$1836.65

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