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Biosensors and Bioelectronics

Biosensors and Bioelectronics

IF: 10.69
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Dynamic and Quantitative Assessment of Quercetin for Cardiac Oxidative Stress Injury Prevention Using Sensitive Cardiomyocyte Based Biosensing

Published:6 December 2024 DOI: 10.1016/j.bios.2024.117045 PMID: 39657554
Jie Chen,?Xuelian Lyu,?Qunchen Yuan,?Chunlian Qin,?Han Yu,?Dongxin Xu,?Jilin Zheng,?Hongchun Li,?Jiaru Fang,?Ning Hu,?Yuqun Cai

Abstract

Myocardial infarction is a leading cause of morbidity and mortality associated with cardiovascular diseases worldwide. Although novel medications and treatments greatly alleviate patient suffering, challenges related to prognostic limit the recovery of cardiac function. Currently, treatment with monomeric compounds displays promise in prognostic interventions for cardiac diseases. However, there is a lack of dynamic and quantitative assessment of cardiomyocyte response to these drugs. Herein, an integrated biosensing platform with a microelectrode array was constructed for label-free, non-invasive, long-term, and real-time recording of cardiomyocyte electrophysiological signals. By analyzing the signals of cardiomyocytes before and after treatment, we established the safe concentration of quercetin in cardiomyocytes and identified its long-term cardiotoxicity. Moreover, quercetin also demonstrated significant protective effects on cardiomyocytes in a H2O2-induced oxidative stress injury model. This study provides a trustworthy platform to evaluate the effects of monomeric compounds on cardiomyocytes, and offers a novel approach for drug screening and efficacy testing in cardiovascular diseases.

Substances (3)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Propidium iodide 25535-16-4 C27H34IN4+ 296 suppliers $29.00-$1780.00
CALCEIN-AM 148504-34-1 C46H46N2O23 135 suppliers $73.00-$2460.00
DAPI 47165-04-8 C16H15N5 13 suppliers $504.53-$504.53

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