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International Journal of Biological Macromolecules

International Journal of Biological Macromolecules

IF: 7.7
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Zinc finger protein rotund is essential for wings and ovarian development by regulating lipid homeostasis in Locusta migratoria

Published:5 December 2024 DOI: 10.1016/j.ijbiomac.2024.138448 PMID: 39645108
Caiyan Huo,?Sikai Liu,?Babar Hussain Chang,?Zhuowang Cheng,?Yanan Zhang,?Weimin Liu,?Jianzhen Zhang,?Xiaoming Zhao

Abstract

Cys2-His2-type zinc finger (C2H2-ZF) proteins are involved in diverse biological processes. In insects, the wing and ovarian development is crucial for reproduction and evolution, yet the physiological roles of C2H2-ZF proteins in these processes remain underexplored. Here, RNA-seq analyses identified C2H2-ZF protein genes that were differentially expressed during wing formation in Locusta migratoria. Among these, the gene encoding a C2H2-ZF protein Rotund (Rn) was highly expressed in the wing pads of fourth- and fifth-instar nymphs. RNA interference mediated knockdown of LmRn in nymph stages resulted in pronounced abnormalities with curled wings and reduced wing area. LmRn knockdown led to reduced expression of lipid transport-related genes during wing morphogenesis, significantly decreased triglyceride (TG) level. In addition, we also find that LmRn knockdown impaired ovarian development and oocyte maturation in female adults, with decreased expression levels of lipid synthesis-related genes, and vitellogenin genes (VgA, and VgB) in the fat body. Meanwhile, the number of lipid droplets, TG content, and protein levels in the ovaries were significantly decreased after LmRn was silenced. Together, our findings reveal that LmRn is essential for wing and ovarian development by regulating lipid homeostasis in locusts, offering a potential target for insect pest management.

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Materials
Procduct Name CAS Molecular Formula Supplier Price
Nile Red 7385-67-3 C20H18N2O2 260 suppliers $38.00-$862.40
DAPI 47165-04-8 C16H15N5 13 suppliers $504.53-$504.53

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