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ACS Applied Bio Materials

ACS Applied Bio Materials

IF: 4.59
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Uridine Metabolism and Its Role in Glucose, Lipid, and Amino Acid Homeostasis.

Published:14 April 2020 DOI: 10.1155/2020/7091718 PMID: 32382566
Yumei Zhang,?Songge Guo,?Chunyan Xie,?Jun Fang

Abstract

Pyrimidine nucleoside uridine plays a critical role in maintaining cellular function and energy metabolism. In addition to its role in nucleoside synthesis, uridine and its derivatives contribute to reduction of cytotoxicity and suppression of drug-induced hepatic steatosis. Uridine is mostly present in blood and cerebrospinal fluid, where it contributes to the maintenance of basic cellular functions affected by UPase enzyme activity, feeding habits, and ATP depletion. Uridine metabolism depends on three stages: de novo synthesis, salvage synthesis pathway and catabolism, and homeostasis, which is tightly relating to glucose homeostasis and lipid and amino acid metabolism. This review is devoted to uridine metabolism and its role in glucose, lipid, and amino acid homeostasis.

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Related products
Procduct Name CAS Molecular Formula Supplier Price
Uridine 58-96-8 C9H12N2O6 831 suppliers $5.00-$35193.00
S-Carboxyethylisothiuronium chloride 5425-78-5 C3H7ClN2O2S 118 suppliers $85.00-$1328.25

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