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Antimicrobial Agents and Chemotherapy

Antimicrobial Agents and Chemotherapy

IF: 4.09
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LC-AMP-I1, a novel venom-derived antimicrobial peptide from the wolf spider Lycosa coelestis

Published:2 December 2024 DOI: 10.1128/aac.00424-24 PMID: 39620694
Junyao Wang,?Xi Liu,?Yuxin Song,?Zhonghua Liu,?Xing Tang,?Huaxin Tan

Abstract

Antibiotic resistance has become a critical concern in recent years, and antimicrobial peptides may function as innovative antibacterial agents to address this issue. In this work, we identified a novel antimicrobial peptide, LC-AMP-I1, derived from the venom of Lycosa coelestis, demonstrating substantial antibacterial properties and minimal hemolytic activity. LC-AMP-I1 was subjected to additional assessment for antibacterial efficacy, anti-biofilm properties, drug resistance, stability, and cytotoxicity in vitro. It exhibited comparable antibacterial efficacy to melittin against six common clinical multidrug-resistant bacteria, effectively inhibiting biofilm formation and disrupting established biofilms. Additionally, LC-AMP-I1 demonstrated minimal bacterial resistance, excellent stability, negligible mammalian cell toxicity, low hemolytic activity, and appropriate selectivity for both normal and tumor cells. When combined with traditional antibiotics, LC-AMP-I1 exhibited additive or synergistic therapeutic effects. In a neutropenic mouse thigh infection model, LC-AMP-I1 exhibited a therapeutic effect in inhibiting bacterial proliferation in vivo. The mechanistic investigation indicated that LC-AMP-I1 could influence bacterial cell membrane permeability at low concentrations and directly disrupt structure-function at high concentrations. The results of this work indicate that LC-AMP-I1 may function as a viable alternative to traditional antibiotics in addressing multidrug-resistant bacteria.

Substances (3)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Erythromycin 114-07-8 C37H67NO13 826 suppliers $5.00-$2245.70
Levofloxacin 100986-85-4 C18H20FN3O4 668 suppliers $5.00-$1504.50
FETUIN 9014-81-7 NULL 66 suppliers $37.07-$4380.00

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