Nicotinamide Riboside Chloride is the chloride salt form of nicotinamide riboside(NR).NR is a new form pyridine-nucleoside of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide(NAD) or NAD+ . Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride is used in dietary supplements.

Nicotinamide riboside is the precursor of nicotinamide adenine dinucleotide (NAD) and represents a source of vitamin B3. Recent studies have shown that ingesting a larger amount of nicotinamide riboside than naturally occurring in foods can provide new health benefits. For example, nicotinamide riboside has been involved in increasing tissue NAD concentration and inducing insulin sensitivity and enhancing deacetylase (sirtuin) function.

Its ability to increase NAD production indicates that nicotinamide riboside can also improve mitochondrial health, stimulate mitochondrial function and induce the production of new mitochondria. Other studies using nicotinamide riboside in Alzheimer's disease models have shown that the molecule is bioavailable to the brain and may provide neuroprotection by stimulating the synthesis of NAD in the brain (ibid.).

In addition, a 2012 study observed that mice on a high-fat diet supplemented with nicotinamide riboside had a 60% reduction in weight gain compared with mice on the same high-fat diet without nicotinamide riboside. Nicotinamide riboside chloride (3-carbamoyl-1-[(2R,3R,4S5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-yl]-pyridine 1-Onium chloride; also known as 1-(β-D-ribofuranosyl)nicotinamide chloride) is a known salt form of nicotinamide riboside, despite the usefulness of nicotinamide riboside and its chloride salt Properties (for example, in medicines or nutritional supplements), but usually need improvement.