中文名稱:ML365 | 英文名稱:ML365 |
CAS:947914-18-3 | 保存條件: -20 ℃ |
純度規(guī)格: 98% min | 產(chǎn)品類別: API |
ML365 is a potent and selective K2P3.1 TASK-1 channel blocker. ML365 blocks TASK1 channels in both the thallium influx fluorescent assay (IC50 = 4 nM) and an automated electrophysiology assay (IC50 = 16 nM). Based on potency differences, it possesses more than 60-fold selectivity for inhibition of TASK1 over a closely-related, two-pore domain potassium channel, TASK3. ML365 displays little or no inhibition at 30 μM of more distantly related potassium channels, Kir2.1, potassium voltage-gated channel, KQT-like subfamily, member 2 (KCNQ2), and human ether-a go-go-related gene (hERG). Based on these criteria, ML365 is a best-in-class probe and is a useful pharmacological probe for in vitro studies of TASK1 function and in further studies aimed at developing therapeutic intervention.
成立日期 | 2011-08-02 (14年) | 注冊(cè)資本 | 200萬(wàn) |
員工人數(shù) | 1-10人 | 年?duì)I業(yè)額 | ¥ 1000萬(wàn)-5000萬(wàn) |
主營(yíng)行業(yè) | 中間體,醫(yī)藥原料,醫(yī)藥中間體,原料藥 | 經(jīng)營(yíng)模式 | 貿(mào)易,工廠,定制 |
產(chǎn)品名稱 | 價(jià)格 | 公司名稱 | 報(bào)價(jià)日期 | |
---|---|---|---|---|
¥266 |
VIP3年
|
TargetMol中國(guó)(陶術(shù)生物)
|
2024-09-30 | |
¥574.90 |
VIP1年
|
上海阿拉丁生化科技股份有限公司
|
2024-08-16 |