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?BTD Antibody
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Cat#：PL0306214
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Isotype:Rabbit Polyclonal IgG
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Immunogen：Peptide derived from human Biotinidase. ?
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Purification:?Immunogen affinity purified
Storage Buffer:?PBS, pH 7.4(1%BSA and 0.1% Sodium azide)
Background：
Biotin, also known as vitamin B7, is an essential water-soluble vitamin that is a cofactor in glucogenesis and in the metabolism of fatty acids and leucine. Biotinidase is a 523 amino acid enzyme that catalyzes the hydrolysis of biocytin to biotin and lysine. Secreted into extracellular space, biotinidase is expressed in liver, heart, placenta, brain, skeletal muscle, pancreas and kidney. Biotinidase contains one carbon-nitrogen hydrolase domain, which is involved in the reduction of organic nitrogen compounds and ammonia production. Defects in the gene encoding biotinidase are the cause of biotinidase deficiency, which is characterized by skin rash, ataxia, seizures, hearing loss, hypotonia and optic atrophy.
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Alternate Names：
Biotinase; Biotinidase; Btd; Sp8; BTD_HUMAN; EC 3.5.1.12. ?
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Specificity Reaction：Hu, Mo, Rat, Chi, Dog, Cow, Hor, , Sheep
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Application Notes:E: 1:500-1000 IHC: 1:100-500 IF: 1:100-500 ICC: 1:100-500
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Storage ：
Store at –20oC for one year. Avoid repeated freeze-thaw cycles. At 4oC for 2-3 weeks after reconstituted.
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This product for research use only, not for use in humans, therapeutic or diagnostic procedures.
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