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抑制劑描述：

產(chǎn)品名稱：U0126

產(chǎn)品別名：1,4-二氨基-2,3-二氰基-1,4-雙(鄰氨基苯巰基)丁二烯

英文別名：U0126;U 0126

靶點：MEK

CAS：109511-58-2

純度：>98%

外觀：Lyophilized powder

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

U-0126 is a selective MAP Kinase Kinase inhibitor, displaying a preference for MEK-1 (IC50 = 72 nM) and MEK-2 (IC50 58nM). It is known that U-0126 binds to MEK in a noncompetitive manner compared to ATP. Studies suggest that U-0126 antagonizes the transcription of AP-1, via the inhibition of MEK. In addition, U-0126 has been observed to inhibit promoters containing an AP-1 response element, while in contrast having no effect on promoters that lack an AP-1 response group. U-0126 is also useful in neuronal studies in mice since it displays inhibitory effects against oxidative stress. U-0126 is an activator of PGC-1, mtTFA and nuclear respiratory factor.

溶解性：Soluble in DMSO at 200 mg/mL

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