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抑制劑描述：
產(chǎn)品名稱：U0126
產(chǎn)品別名：1,4-二氨基-2,3-二氰基-1,4-雙(鄰氨基苯巰基)丁二烯
英文別名：U0126;U 0126
靶點(diǎn)：MEK
CAS：109511-58-2
純度：>98%
外觀：Lyophilized powder
保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
描述：
U-0126 is a selective MAP Kinase Kinase inhibitor, displaying a preference for MEK-1 (IC50 = 72 nM) and MEK-2 (IC50 58nM). It is known that U-0126 binds to MEK in a noncompetitive manner compared to ATP. Studies suggest that U-0126 antagonizes the transcription of AP-1, via the inhibition of MEK. In addition, U-0126 has been observed to inhibit promoters containing an AP-1 response element, while in contrast having no effect on promoters that lack an AP-1 response group. U-0126 is also useful in neuronal studies in mice since it displays inhibitory effects against oxidative stress. U-0126 is an activator of PGC-1, mtTFA and nuclear respiratory factor.
溶解性：Soluble in DMSO at 200 mg/mL
體外研究：
體內(nèi)研究：
產(chǎn)品信息訂購(gòu)：
產(chǎn)品貨號(hào)
產(chǎn)品名稱
規(guī)格
價(jià)格
大包裝及貨期
abs810003
U0126
5mg
400
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