Cell membrane Cleavage furrow Cytoplasm Cytoplasmic side Cytoplasmic vesicle Midbody Nucleus Peripheral membrane protein acrosome cytoskeleton secretory vesicle spindle

This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of Rho-mediated signals. This protein plays a regulatory role in cytokinesis, cell growth, and differentiation. Alternatively spliced transcript variants have been found for this gene. There is a pseudogene for this gene on chromosome 12.