SB 203580(SB203580)

S8307-1MG   2,008.89  SIGMA現(xiàn)貨

信號轉(zhuǎn)導(dǎo)蛋白抑制劑 SB 203580
S8307 - solid, ≥98% (HPLC)   

SB203580也寫作SB 203580或SB-203580，是一種常用的p38 MAPK抑制劑。SB203580可以通透細胞，抑制p38 MAPK(p38 MAP kinase)，抑制后續(xù)MAPKAP Kinase-2和MAPKAP Kinase-3的激活。通過抑制p38 MAPK，SB203580可以有效抑制一些炎癥因子(如IL-1β、TNF-α)誘導(dǎo)的部分信號轉(zhuǎn)導(dǎo)。SB203580選擇性抑制p38 MAPK，IC50為600 nM；對于JNK/SAPK和p44/42 MAPK(即Erk1/2)無顯著的抑制作用，IC50僅為100 μM。
    SB203580分子量為377.43，分子式為C21H16N3FOS，CAS Number：152121-47-6。本產(chǎn)品純度大于99%。
保存條件：
    -20℃避光保存.
注意事項：
    SB203580對人體有刺激性，請注意適當防護。
    本SB203580在4℃、冰浴等較低溫度情況下會凝固而粘在離心管管底、管壁或管蓋內(nèi)，可以20-25℃水浴溫育片刻至全部融解后使用。

[4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole]

M.W. 377.43
 C21H16FN3OS
 [152121-47-6]
 

Storage:  Store at or below -20 ºC.  Solubility:  Soluble in DMSO.  Appearance:  white to off-white solid.  Disposal:  A

View the MSDS for this product

Important, highly specific inhibitor of the kinase known variously as p38, p40, CSBP, or RK.  This kinase is a homolog of MAP kinase.  Gallagher, T.F., et al.  "2,4,5-Triarylimidazole inhibitors of Il-1 biosynthesis."  Bioorg. Med. Chem. Lett. 5:  1171-1176 (1995).  Cuenda, A., et al.  "SB203580 is a specific inhibitor of MAP kinase homologue which is stimulated by cellular stresses and interleukin-1."  FEBS Lett.. 364:  229-233 (1995).  Hazzalin, C.A., et al.  "Effects of the inhibition of p38/RK MAP kinase on induction of five fos and jun genes by diverse stimuli."  Oncogene 15:  2321-2331 (1997).

Sold for laboratory or manufacturing purposes only; not for human, veterinary, food, or household use.

參考資料：

U0126、SB203580、PD98059、LY294002對體外缺氧狀態(tài)下A549細胞侵襲力的影響

絲裂原活化蛋白激酶(MAPK)抑制劑對人精子活動力的影響