Phenacetin
Synonyms:1-Acetyl-p-Phenetidin;4-Acetophenetidide;4-Acetophenetidine;4'-Ethoxyacetanilide;
4-Ethoxyacetanilide;Acetophenetidin;Acetophenetidine;Acet-p-Phenetidine
CAS:62-44-2
MF:C10H13NO2
MW:179.22
EINECS:200-533-0
MP: 133-136 °C(lit.)
BP: 132 °C / 4mmHg
Water Solubility: 0.076 g/100 mL
Chemical property: White shiny flakes or white crystalline powder. Melting point: 137-138°C, Refractive index: 1.571. Insoluble in water, slightly soluble in ether and boiling water, soluble in alcohol and chloroform. No significant color when dissolved in concentrated sulfuric acid, nitric acid dropped into the solution causes orange yellow. Odorless and have a slightly bitter taste.
Usage: Analgesic, antipyretic. Component of APC tablets, analgesic mixture also containing aspirin and caffeine. Phenacetin is reasonably anticipated to be a human carcinogen; analgesic mixtures containing Phenacetin are listed as known human carcinogens.
Air & Water Reactions: Insoluble in water.
Reactivity Profile: Phenacetin react with oxidizing agents, iodine and nitrating agents.
Fire Hazard:Flash point data for Phenacetin are not available but Phenacetin is probably combustible.
Storage Characteristics: Keep a ventilated, low-temperature and dry environment for storehouse; Store separately with reducing agents and food additives.
Uses
1). Used for organic synthesis of raw materials and drug intermediates from acetaminophen ether.
2). Antipyretic analgesics for the treatment of fever, headache, neuralgia.
3). Active pharmaceutical ingredient for Scientific Research.
Test Items Specification Test Results
Description Should comply with the standard Pass
Identification Should be positive reaction Pass
P-Phenetidine Should comply with standard Pass
4-chloroacetanilide Should comply with standard Pass
Sulphated ash ≤0.1% 0.07%
Melting point 134℃ to 136℃ 135.5℃
Assay ≥99% 99.23%
Conclusion Complies with BP68 editio