Human AIMP1 / EMAP2 / SCYE1 Protein, His Tag
分子別名(Synonym)
AIMP1,EMAP2,SCYE1
表達區(qū)間及表達系統(tǒng)(Source)
Human AIMP1, His Tag (EM2-H5142) is expressed from E. coli cells. It contains AA Ala 2 - Lys 312 (Accession # Q12904-1).
Predicted N-terminus: Met
蛋白結構(Molecular Characterization)
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 35.2 kDa. The protein migrates as 36 kDa under reducing (R) condition (SDS-PAGE).
內毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>95% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
Contact us for customized product form or formulation.
重構方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景(Background)
氨基酰基tRNA合酶復合物相互作用多功能蛋白1(AIMP1)也被稱為多合相復合物輔助成分p43和內皮單核細胞激活多肽II(EMAP-II)。AIMP1是一種細胞因子,可由凋亡誘導,也可從樹突狀細胞等專業(yè)抗原呈遞細胞中釋放。AIMP1的釋放使腫瘤相關血管系統(tǒng)對腫瘤壞死因子敏感。此外,AIMP1結合tRNA并刺激細胞質精氨酸-tRNA合酶的催化活性。這種蛋白質具有炎性細胞因子活性。此外,AIMP1通過與SMURF2結合并抑制其SMAD7介導的降解來穩(wěn)定SMURF2,從而負向調節(jié)TGF-β信號傳導。
關鍵字: AIMP1;EMAP2蛋白;SCYE1重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產業(yè)領域提供關鍵生物試劑產品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設有辦公室、研發(fā)中心及生產基地。目前累計服務客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。