化合物 PMX 205|T12506L|TargetMol

價(jià)格	￥6490
包裝	1mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2024-09-30

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產(chǎn)品詳情

中文名稱:化合物 PMX 205	英文名稱:PMX 205
CAS:514814-49-4	品牌: TargetMol
產(chǎn)地: 美國(guó)	保存條件: Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
產(chǎn)品類別: 抑制劑
貨號(hào): T12506L

Product Introduction

Bioactivity

名稱	PMX 205
描述	PMX 205 is an effective complement antagonist of the C5a receptor.
體外活性	In the MTT assay, in 24 h plate, it shows that all groups are significant when compared with negative control group. For the PMX 205 group, the value recorded is between 0.09893 to 0.2465, EP54 group, 0.02724 to 0.1748, and Tamoxifen group, the value recorded in between 0.09880 to 0.2464. Only one group shows a significant result for the 72 h plate, PMX 205 (antagonist group) with the value recorded in between 0.02136 to 0.5322. Only two groups show a significant result for the 48 h plate of incubation time, which are PMX 205 and Tamoxifen. The values recorded are between 0.04987 to 0.3273 and 0.5777 to 0.8551 respectively [1].
體內(nèi)活性	PMX 205 (1 mg/kg/day; SOD1G93A rats; p.o.) from two-time points (days 28 and 70) before the onset of major clinical symptoms. Both treatment groups have a significant extension in survival time compared with untreated rats (p=0.022, day 28; p=0.015, day 70), with no clear differences in outcomes between the two treatment regimens. PMX 205-treated animals also display reduced levels of astroglial proliferation in the lumbar spinal cord. Animals treated with PMX 205 (1 mg/kg/day, oral) show a significant extension of survival time and a reduction in end-stage motor scores, as compared with vehicle-treated rats. Tg2576 mice are treated with PMX 205 (PMX205) at 20 μg/mL in the drinking water (n=17) from 12 to 15 mo of age, the time frame at which there is a rapid accumulation of amyloid deposits in these animals. Untreated Tg2576 animals (n=11) are used as controls. After 3 mo, animals treated with PMX 205 show significantly less fibrillar plaque load (thioflavine reactivity) than do untreated animals. PMX 205 also significantly reduces hyperphosphorylated tau (69%) in 3×Tg mice [2][3].
存儲(chǔ)條件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
關(guān)鍵字	PMX 205 \| PMX205 \| PMX-205

關(guān)鍵字： PMX 205|TargetMol

公司簡(jiǎn)介

TargetMol Chemicals Inc. 總部位于馬薩諸塞州波士頓，致力于為全球生化領(lǐng)域科學(xué)家的研究提供專業(yè)的產(chǎn)品和服務(wù)。TargetMol?品牌的客戶群分布于40多個(gè)國(guó)家和地區(qū)，已發(fā)展成為全球知名的化合物庫(kù)和小分子化合物研究供應(yīng)商。 TargetMol?可提供160多種滿足不同需求的化合物庫(kù)，以及多種類型的生化試劑產(chǎn)品，包括12000多種抑制劑、16000多種天然產(chǎn)物和各類多肽、抗體、生命科學(xué)試劑盒等，此外，我們還建設(shè)有CADD（計(jì)算機(jī)輔助藥物設(shè)計(jì)）研究中心、藥理實(shí)驗(yàn)室、藥化合成平臺(tái)三大技術(shù)中心，全方位滿足客戶的定制需求。憑借我們優(yōu)質(zhì)的產(chǎn)品和服務(wù)、快速高效的全球供應(yīng)鏈和專業(yè)的技術(shù)支持，我們將有效幫助您縮短研發(fā)周期，取得更成功的結(jié)果。

成立日期	2013-04-18 （12年）	注冊(cè)資本	566.265100萬(wàn)人民幣
員工人數(shù)	100-500人	年?duì)I業(yè)額	￥ 1億以上
主營(yíng)行業(yè)	天然產(chǎn)物,生化試劑,分子生物學(xué),分子砌塊,生物技術(shù)服務(wù)	經(jīng)營(yíng)模式	貿(mào)易,工廠,試劑,定制,服務(wù)

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公司成立：12年
注冊(cè)資本：566.265100萬(wàn)人民幣
企業(yè)類型：有限責(zé)任公司(自然人投資或控股)
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