價格 | ¥131 | ¥183 | ¥298 |
包裝 | 1mg | 2mg | 5mg |
最小起訂量 | 1mg |
發(fā)貨地 | 上海 |
更新日期 | 2024-09-29 |
中文名稱:化合物 BIA10-2474 | 英文名稱:BIA 10-2474 |
CAS:1233855-46-3 | 品牌: TargetMol |
產地: 美國 | 保存條件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
純度規(guī)格: 99.79% | 產品類別: 抑制劑 |
貨號: T3354 |
名稱 | BIA 10-2474 |
描述 | BIA 10-2474 is a long-acting reversible inhibitor of fatty acid amide hydrolase (FAAH) that increases levels of the neurotransmitter anandamide in the central nervous system and in peripheral tissues (that is, the rest of the body other than the brain and spinal cord). BIA 10-2474(BIA10-2474) interacts with the human endocannabinoid system. BIA 10-2474(BIA10-2474) was in development for the treatment of a range of different medical conditions from anxiety to Parkinson's disease, also for the treatment of chronic pain of multiple sclerosis, Y, hypertension or the treatment of obesity. |
體外活性 | ExVivo: BIA 10-2474 proves to be a potent FAAH inhibitor with IC50s of 50-70 mg/kg (i.p.) in various brain regions. IC50 values for brain regions are 52 (cerebellum), 67 (rest of brain), 68 (cortex), and 71 mg/kg (hypothalamus)[1]. |
體內活性 | In January 2016, severe adverse events (SAE) occurs in the Phase I Clinicalal trial using the drug BIA 10-2474 including one death. The possibilities for failure of trials such as off-target effect, dose calculation, unexpected immune response, species variation, and cumulative dose toxicity would be sought[2]. |
存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 4 mg/mL (13.3 mM) |
關鍵字 | Inhibitor | inhibit | Fatty acid amide hydrolase | FAAH | BIA 10-2474 | BIA 102474 | BIA 10 2474 | Autophagy |
相關產品 | Guanidine hydrochloride | Naringin | Valproic Acid | Taurine | Gefitinib | Aceglutamide | Hydroxychloroquine | Curcumin | Stavudine | Salicylic acid | Paeonol | Sodium 4-phenylbutyrate |
相關庫 | 抑制劑庫 | 抗帕金森病化合物庫 | 經典已知活性庫 | 已知活性化合物庫 | 代謝化合物庫 | ReFRAME 相關化合物庫 | NO PAINS 化合物庫 | 抗肥胖化合物庫 | 神經退行性疾病化合物庫 | 藥物功能重定位化合物庫 | 疼痛相關化合物庫 | 抗代謝疾病化合物庫 |
成立日期 | 2013-04-18 (12年) | 注冊資本 | 566.265100萬人民幣 |
員工人數(shù) | 100-500人 | 年營業(yè)額 | ¥ 1億以上 |
主營行業(yè) | 天然產物,生化試劑,分子生物學,分子砌塊,生物技術服務 | 經營模式 | 貿易,工廠,試劑,定制,服務 |
產品名稱 | 價格 | 公司名稱 | 報價日期 | |
---|---|---|---|---|
詢價 |
VIP1年
|
青島愷潤生物醫(yī)藥科技有限公司
|
2024-11-02 | |
¥198 |
VIP12年
|
上海陶術生物科技有限公司
|
2024-10-18 | |
詢價 |
VIP1年
|
陜西西化化學工業(yè)有限公司
|
2024-10-15 | |
¥1935.90 |
VIP1年
|
上海阿拉丁生化科技股份有限公司
|
2024-08-16 |