Mouse FcRn / FCGRT&B2M Heterodimer Protein, His Tag (MALS & BLI verified)
分子別名（Synonym）
FcRn,FCGRT & B2M
表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）
Mouse FCGRT&B2M Heterodimer Protein, His Tag (FCM-M52W8) is expressed from human 293 cells (HEK293). It contains AA Ser 22 - Ser 297 (FCGRT) & Ile 21 - Met 119 (B2M) (Accession # Q61559-1 (FCGRT) & P01887-1 (B2M)).
Predicted N-terminus: Ser 22 (FCGRT) & Ile 21 (B2M)
蛋白結(jié)構(gòu)（Molecular Characterization）
Mouse FCGRT&B2M Heterodimer Protein, His Tag, produced by co-expression of FCGRT and B2M, has a calculated MW of 32.9 kDa (FCGRT) and 11.6 kDa (B2M). Subunit FCGRT is fused with a polyhistidine tag at the C-terminus and subunit Beta-2 microglobulin (B2M) contains no tag at the C-terminus. The reducing (R) protein migrates as 40-50 kDa (FCGRT) and 13 kDa (B2M) respectively due to glycosylation.
內(nèi)毒素（Endotoxin）
Less than 1.0 EU per μg by the LAL method.
純度（Purity）
>95% as determined by SDS-PAGE.
>95% as determined by SEC-MALS.
制劑（Formulation）
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法（Reconstitution）
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(chǔ)（Storage）
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 12 months under sterile conditions after reconstitution.
背景（Background）
FCGRT和B2M異二聚體蛋白（FcRn復(fù)合物）由兩個(gè)亞基組成：p51（相當(dāng)于FCGRT）和p14（相當(dāng)于β-2-微球蛋白），形成MHC I類(lèi)異二聚物。IgG、受體、轉(zhuǎn)運(yùn)蛋白、α（FCGRT）的Fc片段與單體免疫球蛋白γ的Fc區(qū)結(jié)合，并介導(dǎo)從牛奶中攝取IgG。FCGRT可能在免疫球蛋白G從母體轉(zhuǎn)移到胎兒中發(fā)揮作用。β2-微球蛋白（B2M）是I類(lèi)主要組織相容性復(fù)合體（MHC）的一種成分，參與向免疫系統(tǒng)呈遞肽抗原。
關(guān)鍵字： FcRn (FCGRT & B2M);FcRn蛋白;FCGRT蛋白;ACRO;百普賽斯;
百普賽斯集團(tuán)ACROBiosystems Group（股票代碼：301080）是成立于2010年的跨國(guó)生物科技公司，是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺(tái)型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團(tuán)業(yè)務(wù)遍布全球，橫跨亞洲、北美洲、歐洲，在中國(guó)、美國(guó)、瑞士等12個(gè)城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計(jì)服務(wù)客戶(hù)超6000家，與全球Top 20醫(yī)藥企業(yè)均建立了長(zhǎng)期、穩(wěn)定的合作伙伴關(guān)系。集團(tuán)旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。