地夸磷索四鈉|T7423|TargetMol

2篇文獻(xiàn)

價(jià)格	￥256	￥365	￥592
包裝	1mg	2mg	5mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2024-12-02

QQ交談微信洽談

產(chǎn)品詳情

中文名稱:地夸磷索四鈉	英文名稱:Diquafosol tetrasodium
CAS:211427-08-6	品牌: TargetMol
產(chǎn)地: 美國(guó)	保存條件: keep away from direct sunlight,store under nitrogen \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
純度規(guī)格: 99.97%	產(chǎn)品類別: 抑制劑
貨號(hào): T7423

Product Introduction

Bioactivity

名稱	Diquafosol tetrasodium
描述	Diquafosol Tetrasodium is a P2Y2 receptor agonist that stimulates the secretion of mucins from ocular tissues Diquafosol tetrasodium (INS365) improves tear film stability and visual function, as a topical treatment of dry eye disease.
細(xì)胞實(shí)驗(yàn)	The viabilities of human corneal epithelial cells (HCECs) were determined using a MTT assay.?Cells (100 μl;?5×104 cell/mL) were plated in 96-well tissue-culture plates and incubated at 37℃ in 5% CO2 for 24 to 48 h until cultures were subconfluent.?Diquafosol (100 μl diluted 10%, 20%, or 30%) or 0.3% or 0.18% HA were added and incubated for 1, 6, or 24 h. DMEM (100 μl) was added to controls.?After 1, 6, and 24 h, plates were washed three times with PBS to remove the drugs.?Cell viabilities were evaluated after incubating for 24 h. MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide;?thiazoyl blue (5 mg/mL) was then added to each well.?Samples were incubated in the dark for 4 h at 37℃, and media were then removed.?Precipitates were resuspended indimethyl sulfoxide (100 μl;?DMSO, Sigma-Aldrich).?Absorbances were measured on a plate reader at 570 nm.?The experiment was performed in triplicate[1].
動(dòng)物實(shí)驗(yàn)	An SD rat dry eye model was used in which exorbital lacrimal gland extirpation decreased the Schirmer test score by at least 50%. After 8 weeks, when significant increases occurred in corneal epithelial permeability, Diquafosol tetrasodium(INS365)-containing eye drops were applied six times daily for the next 4 weeks at concentrations from 0.03% to 3.0%. Corneal barrier function was evaluated based on measurements with a modified anterior fluorometer of fluorescein penetrance at 1, 2, and 4 weeks after initial application. After INS365 application, the periodic acid-Schiff reagent (PAS)-stained area was evaluated in histologic sections of the tarsal and bulbar conjunctiva[2].
體外活性	曝露時(shí)間和diquafosol濃度顯著降低了細(xì)胞存活率并增加了細(xì)胞裂解。相反，HA組中無論曝露時(shí)間長(zhǎng)短，觀察到的差異均不顯著。用30%稀釋的diquafosol處理1小時(shí)后以及用所有濃度稀釋的diquafosol處理6小時(shí)后，細(xì)胞活力顯著下降。經(jīng)過24小時(shí)所有濃度稀釋的diquafosol處理后，細(xì)胞存活率降低，裂解增加，觀察到顯著的細(xì)胞損傷[1]。
體內(nèi)活性	在大鼠干眼模型中，P2Y(2) 激動(dòng)劑 INS365 能夠改善眼表健康，這一發(fā)現(xiàn)基于幾方面的增加：淚液分泌、角膜上皮抵抗力以及杯狀細(xì)胞釋放含有糖蛋白的組分。因此，INS365 是治療干眼綜合征的潛在治療劑。
存儲(chǔ)條件	keep away from direct sunlight,store under nitrogen \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	H2O : 10 mM DMSO : Insoluble
關(guān)鍵字	Inhibitor \| Diquafosol tetrasodium \| inhibit \| INS 365 \| Diquafosol \| INS-365 \| P2Y Receptor
相關(guān)產(chǎn)品	Clopidogrel \| PSB-16133 sodium \| cangrelor tetrasodium \| Clopidogrel hydrogen sulfate \| Prasugrel Hydrochloride \| AZD1283 \| (±) Clopidogrel hydrogen sulfate \| Uridine-5'-diphosphate disodium salt \| N6-(4-Hydroxybenzyl)adenosine \| Prasugrel \| Regrelor disodium \| Uridine 5′-diphosphoglucose disodium salt
相關(guān)庫	抗癌上市藥物庫 \| 經(jīng)典已知活性庫 \| 已知活性化合物庫 \| 上市藥物庫 \| 抗病毒庫 \| GPCR靶點(diǎn)分子庫 \| 膜蛋白靶向化合物庫 \| 藥物功能重定位化合物庫 \| 抗癌臨床化合物庫 \| 抗癌藥物庫

關(guān)鍵字：地夸磷索四鈉|||INS365|TargetMol

公司簡(jiǎn)介

上海陶術(shù)生物科技有限公司為美國(guó)Target Molecule Corp. ( Target Mol ) 在上海建立的全資子公司。我們與美國(guó)波士頓、德國(guó)慕尼黑的同事一起，為北美、歐洲和亞洲從事藥物研發(fā)和生物學(xué)研究的科學(xué)家提供優(yōu)質(zhì)的產(chǎn)品和專業(yè)的服務(wù)。公司下設(shè)篩選事業(yè)部，化學(xué)事業(yè)部，生物事業(yè)部和新材料部。從虛擬篩選到實(shí)體化合物分子供應(yīng)；從商業(yè)化產(chǎn)品銷售到個(gè)性化定制合成；從對(duì)明確靶點(diǎn)的分子篩選到對(duì)明確分子的多靶點(diǎn)篩選，從高通量篩選到化學(xué)結(jié)構(gòu)優(yōu)化，我們都可以滿足您的科研用品及技術(shù)服務(wù)的需求。經(jīng)過在中國(guó)市場(chǎng)五年的精心耕耘，我們已成為篩選化合物領(lǐng)域優(yōu)秀的供應(yīng)商，為超過五百家學(xué)校和各類企業(yè)提供了品質(zhì)卓越的小分子化合物和藥物篩

成立日期	2013-04-18 （12年）	注冊(cè)資本	566.2651萬人民幣
員工人數(shù)	100-500人	年?duì)I業(yè)額	￥ 1億以上
主營(yíng)行業(yè)	化學(xué)試劑,生物活性小分子	經(jīng)營(yíng)模式	貿(mào)易,試劑,定制,服務(wù)

TargetMol中國(guó)（陶術(shù)生物）

VIP 12年

公司成立：12年
注冊(cè)資本：566.2651萬人民幣
企業(yè)類型：有限責(zé)任公司(自然人投資或控股)
主營(yíng)產(chǎn)品：小分子抑制劑，藥物篩選化合物庫，天然產(chǎn)物，活性分子化合物等
公司地址：上海市閘北區(qū)江場(chǎng)三路28號(hào)4樓

進(jìn)入店鋪

詢盤

店內(nèi)推薦

化合物 Haloxyfop-P-methyl|T82240|TargetMol

詢價(jià)

頭孢拉定|T0199|TargetMol

￥132

化合物 2-Azaspiro[4.5]decan-3-one|T67358|TargetMol

詢價(jià)