Human Tau-441 / 2N4R Pre-formed Fibrils Protein, Tag Free
分子別名(Synonym)
DDPAC,FTDP-17,MAPT,MSTD,MTBT1,Tau,PHF-tau,TAU
表達區(qū)間及表達系統(tǒng)(Source)
Human Tau-441 Pre-formed Fibrils, Tag Free (TAU-H5115) is expressed from E. coli cells. It contains AA Met 1 - Leu 441 (Accession # P10636-8).
Predicted N-terminus: Met 1
蛋白結(jié)構(gòu)(Molecular Characterization)
This protein carries no "tag".
The protein has a calculated MW of 45.8 kDa. The protein migrates as 30-53 kDa and 55-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>90% as determined by SDS-PAGE.
制劑(Formulation)
Supplied as 0.2 μm filtered solution in PBS, pH7.4.
Contact us for customized product form or formulation.
運輸(Shipping)
This product is supplied and shipped with dry ice, please inquire the shipping cost.
存儲(Storage)
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
The product should be stored at -70°C or room temperature for short storage. Do not store fibrils on ice or at 4°C;
The unsonicated fibril is validated to be stable after storage at -70°C for 1 year under sterile conditions;
The sonicated fibril should be stored at -70°C for not more than 8 weeks.
背景(Background)
Tau是一種微管相關(guān)蛋白,由位于染色體17q21上的MAPT基因編碼。Tau促進微管組裝和穩(wěn)定性,可能參與神經(jīng)元極性的建立和維持。tau蛋白的過度磷酸化(tau內(nèi)含物,pTau)可導(dǎo)致成對螺旋絲和直絲纏結(jié)的自組裝,這與阿爾茨海默病、額顳葉癡呆和其他tau病的發(fā)病機制有關(guān)。
關(guān)鍵字: Tau;Tau蛋白;Tau重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務(wù)遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計服務(wù)客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關(guān)系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。