Human LRRC15-coupled Magnetic Beads

背景（Background）

LRRC15 (Leucine-rich repeat-containing protein 15) is also known as LIB and hLib. LRRC15 is highly expressed in a variety of solid tumors. LRRC15 was expressed on stromal fibroblasts in many solid tumors (e.g., breast, head and neck, lung, pancreatic) as well as directly on a subset of cancer cells of mesenchymal origin (e.g., sarcoma, melanoma, glioblastoma). LRRC15 expression was induced by TGFβ on activated fibroblasts (αSMA+) and on mesenchymal stem cells. These collective findings suggested LRRC15 as a novel CAF and mesenchymal marker with utility as a therapeutic target for the treatment of cancers with LRRC15-positive stromal desmoplasia or cancers of mesenchymal origin. ABBV-085 is a monomethyl auristatin E (MMAE)-containing antibody–drug conjugate (ADC) directed against LRRC15, and it demonstrated robust preclinical efficacy against LRRC15 stromal-positive/cancer-negative, and LRRC15 cancer-positive models as a monotherapy, or in combination with standard-of-care therapies.

應(yīng)用說明（Application）

This product is labeled by APC and coupled by CD47 protein in advance, no need to use fluorescent labeled secondary antibody, easy to flow cytometry.

The Isotype control (Cat. No. SMB-B01) is sold separately.

重構(gòu)方法（Reconstitution）

See Certificate of Analysis (CoA) for detailed instruction.

存儲(chǔ)（Storage）

Store beads at 2° to 8°C and protected from direct light. Do not use after the expiration date shown on the label.

Please avoid more than 3 freeze-thaw cycles. Immediate use after reconstitution is highly recommended.

制劑（Formulation）

Please contact us for detailed information.

Contact us for customized product form or formulation.