| 中文名 | 鹽酸依伐布雷定
|
| 英文名 | Ivabradine hydrochloride
|
| 別名 | 鹽酸伊伐布雷
鹽酸伊伐布雷定
鹽酸依伐布雷定
鹽酸伊伐布雷啶
鹽酸依法布雷定
依伐布雷定鹽酸鹽
鹽酸伊伐布雷定及中間體
鹽酸伊伐布雷定(依法布雷定)
鹽酸伊伐布雷定IVABRADINE(研發(fā)中)
3-[3-[[(8S)-3,4-二甲氧基-8-雙環(huán)[4.2.0]辛-1,3,5-三烯]甲基-甲氨基]丙基]-7,8-二甲氧基-2,5-二氫-1H-3-苯并氮雜卓-4-酮鹽酸鹽
|
| 英文別名 | Corlentor
Ivabradine HCl
Ivabradine hydrochloride
IVABRADINE HYDROCHLORIDE-OTHER COMPOUNDSCONTAINING AN UNFUSED PYRAZOLE RING(WHETHER OR NOT HYDROGENATED)IN THE STRUCTUR
3-[3-[[(8S)-3,4-Dimethoxy-8-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one hydrochloride
3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one Hydrochloride
3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino]propyl}-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one hydrochloride
|
| CAS | 148849-67-6
|
| EINECS | 638-798-3 |
| 化學式 | C27H36N2O5.HCl
|
| 分子量 | 505.05 |
| InChI | InChI=1/C27H36N2O5.ClH/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30;/h12-14,16,21H,6-11,15,17H2,1-5H3;1H/t21-;/m1./s1 |
| InChIKey | HLUKNZUABFFNQS-ZMBIFBSDSA-N |
| 熔點 | 193-196?C |
| 沸點 | 626.9°C at 760 mmHg |
| 比旋光度 | 58921 +7.8°; 36521 +27.8° (c = 1% in DMSO) |
| 閃點 | 332.9°C |
| 蒸汽壓 | 1.24E-15mmHg at 25°C |
| 溶解度 | H2O: ≥ 5mg/ml (溫熱) |
| 存儲條件 | 2-8°C |
| 外觀 | 粉末 |
| 顏色 | white to beige |
| Merck | 14,5247 |
| MDL號 | MFCD00929899 |
| 體內(nèi)研究 | Ivabradine hydrochloride treatment (10 mg/kg/d) induces long-term HRR, and that improves diastolic LV function probably involving attenuated hypoxia, reduced remodeling, and/or preserved nitric oxide bioavailability, resulting from processes triggered early after HRR initiation: angiogenesis and/or preservation of endothelial nitric oxide synthase expression. Ivabradine hydrochloride leads to a sustained 15-20% heart rate reduction, but has no effect on blood pressure. While ivabradine has no effect on endothelial function and vascular reactive oxygen species production in angiotensin II-treated rats, it improves both parameters in ApoE knockout mice. Ivabradine hydrochloride treatment leads to an attenuation of angiotensin II signaling and increased the expression of telomere-stabilizing proteins in ApoE knockout mice, which may explain its beneficial effects on the vasculature. The absence of these protective ivabradine effects in angiotensin II-infused rats may relate to the treatment duration or the presence of arterial hypertension. |
| 危險品標志 | N - 危害環(huán)境的物品
|
| 風險術語 | 50/53 - 對水生生物有極高毒性，可能對水體環(huán)境產(chǎn)生長期不良影響。
|
| 安全術語 | S60 - 該物質及其容器須作為危險性廢料處置。
S61 - 避免釋放至環(huán)境中。參考特別說明/安全數(shù)據(jù)說明書。
|
| 危險品運輸編號 | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| 上游原料 | 脫氫伊伐布雷定 (1S)-4,5-二甲氧基-1-[(甲基氨基)甲基]苯并環(huán)丁烷鹽酸鹽 |