中文名：Naproxen Sodium

英文名：Naproxen Sodium

英文別名：RS-3650;sodium (S)-2-(6-methoxynaphthalen-2-yl)propanoate

純度：10mM in DMSO

貨號(hào)：N407750

包裝：1ml

Cas號(hào)：26159-34-2

存儲(chǔ)溫度：-80℃儲(chǔ)存

產(chǎn)品介紹：

Information

Naproxen Sodium (RS-3650) is a COX inhibitor forCOX-1andCOX-2withIC50of 8.7 μM and 5.2 μM, respectively.
In?vitro

Naproxen is approximately equipotent inhibitor of COX-1 and COX-2 in intact cells with IC50 of 2.2 μg/mL and 1.3 μg/mL, respectively. Naproxen decreases the in vitro LPS-induced PGE₂ and TXB₂ production in rats and humans with IC50 of 30.7 μM and 79.5 μM for PGE₂ inhibition, 72.4 μM and 48.3 μM for TXB₂ inhibition, respectively. Naproxen produces concentration-related inhibition of TXB₂ production from human platelets and LPS-induced TXB₂ production from human mononuclear cells with plC50 values (-log concentration inhibiting TXB₂ by 50%) of 5.7 and 6.4, respectively, and exhibits slightly inhibitory selectivity for constitutive and induced COX-2 with IC50 COX-1/IC50 COX-2 of 6.3. Only high concentration of Naproxen can significantly induce apoptosis at 48 hours in HCA-7 colon cancer cells with IC50 of 1.45 mM.

In?vivo

Administration of Naproxen reduces the LPS-induced PGE₂ and TXB₂ production in vivo in rats with IC50 values of 12.8 μM and 5.9 μM, respectively, which represents that Naproxen is a nonselective COX inhibitor with the log IC50 ratio (COX-2/COX-1) of 0.34. Naproxen displays IC50 of 27 μM for analgesia in a rat model with carrageenan-induced arthritis and IC50 of 40 μM for antipyretics in a yeast-induced fever rat model, while exhibits inhibition of PGE₂ with IC50 of 13 μM and TXB₂ with IC50 of 5 μM.
Cell?Data

cell?lines：

Concentrations：Dissolved in culture medium, final concentration ~20 mM

Incubation?Time：24 and 48 hours

Powder?Purity:≥99%

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