中文名：Medetomidine HCl
英文名：Medetomidine HCl
英文別名：1H-Imidazole, 5-[1-(2,3-dimethylphenyl)ethyl]-, hydrochloride (1:1)
純度：10mM in DMSO
貨號：M409157
包裝：1ml
Cas號：86347-15-1
存儲溫度：-80℃儲存
產(chǎn)品介紹：
Information
Medetomidine is a selectiveα2-adrenoceptoragonist, withKiof 1.08 nM, exhibts 1620-fold selectivity over α1-adrenoceptor.
In?vitro
Medetomidine is a selectiveα2-adrenoceptor agonist, with Ki of 1.08 nM, exhibits 1620-fold selectivity over α1-adrenoceptor, has very weak or no binding to other neurotransmitter receptors.
In?vivo
In anesthetized rats, medetomidine (1-100 μg/kg, i.v.) induces a dose-dependent, relatively short-lived reduction in blood pressure and heart rate. In the pithed rat, medetomidine shows very potent vasopressor (PD50 1.7 μg/kg) and sympatho-inhibitory (ID50 1.6 μg/kg) effects without affecting basal heart rate. Medetomidine induces dose-dependent sedation, which at high doses (>100μg/kg) includes loss of the righting reflex and hypothermia. Medetomidine induces a decreases in the turnover rate of biogenic amines in the brain, dose-dependently inhibits norepinephrine (NE) turnover, inhibits brain dopamine turnover at high doses, decreases serotonin turnover.
Cell?Data
cell?lines：Human microvascular endothelial cell line HMEC-1
Concentrations：
Incubation?Time：
Powder?Purity:≥99%
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關(guān)鍵字： 1H-Imidazole, 5-[1-(2,3-dimethylphenyl)ethyl]-, hydrochloride (1:1)
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