中文名：依碳酸氯替潑諾
英文名：Loteprednol etabonate
英文別名：(11β,?17α)?-7-?[(ethoxycarbonyl)?oxy]?-?11-?hydroxy-?3-?oxo-androsta-?1,?4-?diene-?17-?carboxylic acid chloromethyl ester
純度：10mM in DMSO
貨號(hào)：L408801
包裝：1ml
Cas號(hào)：82034-46-6
存儲(chǔ)溫度：-80℃儲(chǔ)存
產(chǎn)品介紹：
Information
Loteprednol etabonate Loteprednol etabonate is a potent glucocorticoid receptor agonist, used in treatment of inflammation of the eye due to allergies.
In?vitro
Loteprednol possesses a metabolically labile function, the 17beta-ester, that is designed to be rapidly deactivated in the systemic circulation. Loteprednol etabonate exhibits a binding affinity which is 4.3 times that of dexamethasone, both compounds having a Hill factor close to 1 whereas PJ90 and PJ91 does not show any affinity to the receptor.
In?vivo
Loteprednol etabonate administrated directly into the joint effectively blocks the inflammatory response. Loteprednol etabonate prevents the adverse inflammatory effects of antigen action in a rabbit acute experimental model for arthritis. Loteprednol etabonate (LE) (oral) reaches the upper GI tract effectively, but not the colon, due to absorption and/or decomposition in rats. Loteprednol etabonate (LE) shows a rapid, dose-dependent elimination with a total blood clearance (CLtotal) of higher than 60 ml/min/kg in rats. Loteprednol etabonate absorbes systemically, after topical administration, can be rapidly transformed to the inactive metabolites, and eliminates from the body mainly through the bile and urine.
Cell?Data
cell?lines：
Concentrations：
Incubation?Time：
Powder?Purity:≥99%
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關(guān)鍵字： (11β,?17α)?-7-?[(ethoxycarbonyl)?oxy]?-?11-?hydroxy-?3-?oxo-androsta-?1,?4-?diene-?17-?carboxylic acid chloromethyl ester
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