中文名：依那普利馬來酸鹽
英文名：Enalapril Maleate
英文別名：MK-421 Maleate;N-?[(1S)?-?1-?(ethoxycarbonyl)?-?3-?phenylpropyl]?-?L-?alanyl-?L-?proline,(2Z)?-?2-?butenedioate (1:1)
純度：10mM in DMSO
貨號(hào)：E408277
包裝：1ml
Cas號(hào)：76095-16-4
存儲(chǔ)溫度：-80℃儲(chǔ)存
產(chǎn)品介紹：
Information
Enalapril (MK-421) Maleate is anangiotensin-converting enzyme (ACE)inhibitor, used in the treatment of hypertension, diabetic nephropathy, and chronic heart failure.
In?vitro
Enalapril\xa0is rapidly converted by ester hydrolysis to enalaprilat, a potent ACE\xa0inhibitor;\xa0Enalapril\xa0itself is only a weak ACE\xa0inhibitor.\xa0Enalapril\xa0lowers peripheral vascular resistance without causing an increase in heart rate.\xa0
In?vivo
Enalapril\xa0treatment\xa0abolishes the deleterious effects of\xa0eNOS\xa0deficiency on blood pressure (BP),\xa0atherosclerosis, and\xa0kidney dysfunction\xa0in nnee\xa0mice. Enalapril\xa0causes a dose-dependent increase in fore limb strength\xa0in the\xa0mdx\xa0mouse. Enalapril\xa0causes a dose-dependent reduction of superoxide anion production\xa0in tibialis anterior\xa0muscle\xa0of the\xa0mdx\xa0mouse as observed by dihydroethidium staining.\xa0Enalapril\xa0(5 mg/kg) reduces the area of\xa0muscle\xa0necrosis in both gastrocnemious\xa0muscle\xa0and diaphragm, without significant effect on non-muscle\xa0area. Enalapril Maleate results in significant increases in kidney weight and in concentrations of urinary albumin, N-acetyl-fl-d-glucosamidase (NAG) and serum ET-1 in streptozotocin (STZ)-induced\xa0diabetic (STZ-DM)\xa0rats as compared with the non-diabetic\xa0rats, and the concentration of ET-1 in the kidneys tended to be increased. Enalapril Maleate results in increased mesangial cell proliferation, matrix expansion and enlarged mesangial area in the kidney of the\xa0diabetic\xa0rats.\xa0Enalapril Maleate reduces increased concentrations of urinary albumin and NAG in the STZ-DM\xa0rats to the control values with a slight improvement in the electron microscopic\xa0changes.
Cell?Data
cell?lines：
Concentrations：
Incubation?Time：
Powder?Purity:≥99%
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關(guān)鍵字： MK-421 Maleate;N-?[(1S)?-?1-?(ethoxycarbonyl)?-?3-?phenylpropyl]?-?L-?alanyl-?L-?proline,(2Z)?-?2-?butenedioate (1:1)
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