中文名：醋酸普蘭林肽

英文名：Pramlintide Acetate

英文別名：Tripo-amylin Acetate Hydrate; AC-137 Acetate Hydrate, Symlin Acetate Hydrate

純度：98%

貨號：P334885

包裝：2.5mg、25mg、100mg

Cas號：196078-30-5

存儲溫度：-20°C儲存

產(chǎn)品介紹：

product description：?

Pramlintide is a non-amyloidogenic analog of the antidiabetic peptide hormone amylin that contains proline residues substituted at positions 25, 28, and 29. It stimulates cAMP production in HEK293 cells expressing human amylin receptor 1a (AMY1a), AMY2a, and AMY3a (EC50s = 0.35, 22.9, and 0.89 nM, respectively). Pramlintide inhibits human islet amyloid polypeptide fibrilization in a concentration-dependent manner. In vivo, pramlintide (200 pg/kg) reduces brain levels of amyloid-β (1-40) and increases spontaneous alternation in the Y-maze in the Tg2576 transgenic mouse model of Alzheimer's disease.

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