應(yīng)用
CASIN has been used as a cell division control protein 42 homolog (Cdc42) inhibitor:to study its effects on the stimulation of extracellular vesicles (EVs) in intestinal epithelial cellsto study its effects on mice jejunumto study its effects on microbial adhesion-triggered endocytosis (MATE) vesicle morphology in segmented filamentous bacteria (SFB)-colonized mice
生化/生理作用
CASIN是Cdc42 GTPase的抑制劑,Cdc42 GTPase是Rho亞家族的一種小GTP酶,在細(xì)胞骨架組織、細(xì)胞周期進(jìn)程、信號(hào)轉(zhuǎn)導(dǎo)和囊泡運(yùn)輸中起重要作用。 CASIN產(chǎn)生了造血干細(xì)胞(HSC)的恢復(fù)活力的表型,將衰老的HSC的衰老相關(guān)和極性表型逆轉(zhuǎn)為體內(nèi)年輕的HSC 的衰老相關(guān)和極性表型。
Sigma-Aldrich西格瑪奧德里奇(上海)貿(mào)易有限公司
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