Rabbit Anti-E2F4 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:E2F4
IR:Immunogen Range:1-150/413
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:1874
Swiss Prot:Q16254
Source:KLH conjugated synthetic peptide derived from human E2F4:1-150/413
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008]
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IP(1:20-100)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Chicken
Dog
Pig
Cow
Horse
僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關(guān)鍵字： E2F4;E2F 4;E2F transcription fa;E2F transcription fa;p107/p130 binding pr;Transcription factor;Transcription factor;E2F4_HUMAN;
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