Product Name：GLP-1(7-36)
CAS No.：89750-14-1；107444-51-9
Synonyms：GLP-1-(7-36) amide；Glucagon-like peptide I；胰高血糖素樣肽7-36
Catalog No.：153P05
Brand：HongTide（上海鴻肽生物）
Description：GLP-1是人體分泌的一種腸道激素，由胰高血糖素原(Proglucagon)分子經(jīng)腸道蛋白水解酶作用而產(chǎn)生，因而稱為胰高血糖素類多肽或胰高血糖素樣肽，GLP-1(7-36)是其中的一種。生物體內(nèi)的GLP-1有二種形式，一種為GLP-1(7-36)，是由30個(gè)氨基酸殘基組成的多肽，肽鏈C端乙?；涣硪环N為GLP-1(7-37)，是由31個(gè)氨基酸殘基組成的多肽。GLP-1(7-36)和GLP-1(7-37)有相同的促胰島素分泌作用。研究表明當(dāng)血糖濃度高于6mmol/L時(shí)，GLP-1能顯著促進(jìn)胰島素分泌；而一旦血糖濃度恢復(fù)至正常值則不再繼續(xù)作用，在臨床上這一點(diǎn)對II型糖尿病的治療十分有用。
GLP-1 is an intestinal hormone secreted by the human body, which is produced by the action of Glucagon molecule through intestinal protein Hydrolase, so it is called Glucagon like peptide or Glucagon like peptide. GLP-1 (7-36) is one of them. There are two forms of GLP-1 in living organisms, one is GLP-1 (7-36), which is a peptide composed of 30 amino acid residues and acetylated at the C-end of the peptide chain; The other type is GLP-1 (7-37), which is a peptide composed of 31 amino acid residues. GLP-1 (7-36) and GLP-1 (7-37) have the same proinsulin secretion effect. Research has shown that GLP-1 can significantly promote insulin secretion when blood glucose concentration is higher than 6mmol/L; Once the blood glucose concentration returns to the normal value, it will not continue to function, which is very useful for the treatment of type II diabetes clinically.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | HAEGTFTSDVSSYLEGQAAKEFIAWLVKGR-NH2 |
Sequence(3-letter code) | H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2 |
Peptide Structure | 
|
Molecular Formula | C149H226N40O45 |
Molecular Weight | 3297.68 |
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上海鴻肽生物科技有限公司（簡稱：鴻肽生物）是一家以多肽以及多肽上下游產(chǎn)品研發(fā)、生產(chǎn)、銷售以及技術(shù)轉(zhuǎn)讓為主要業(yè) 務(wù)科技公司。公司現(xiàn)有產(chǎn)品涵蓋：定制多肽、目錄多肽、氨基酸衍生物、小分子化合物；公司自成立以來，秉持“用質(zhì)量作船， 以服務(wù)為帆，為科研服務(wù)”的企業(yè)理念，為國內(nèi)外眾多科研工作者提供了優(yōu)質(zhì)的服務(wù)及產(chǎn)品。