Host:Rabbit

Target Protein:TCF7L2

IR:Immunogen Range:

Clonality:Monoclonal

Isotype:IgG

Entrez Gene:6934

Swiss Prot:Q9NQB0

Source:KLH conjugated synthetic peptide derived from human TCF7L2: 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:TCF-4, transcription factor 4, is a basic helix-turn-helix transcription factor. This protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. The gene for TCF-4 is expressed predominantly in pre-B-cells, although it is found in other tissues as well. Multiple alternatively spliced transcript variants that encode different proteins have been described. TCF4, also known as TCF7L2, is expressed widely during development. Gene targeting study indicates that it is required to maintain the crypt stem cells of the small intestine. TCF4 has many different splicing isoforms and they are expressed differentially in tissues and in cancers of different stages. Studies also indicate that variant of the TCF4 gene confers an increased risk of type 2 diabetes.

Size:50ul

Concentration:1mg/ml

Applications:WB(1:500-1000)
IP(1:20-100)
IHC-P(1:50-200)
Flow-Cyt(1:50)
ICC(1:100)
IF(1:50-200)

Cross Reactive Species:Human
Mouse
Rat

本產(chǎn)品僅供科研使用。不能用于人和動物治療等其它臨床診斷使用！