Host:Rabbit
Target Protein:Phospho-PKC alpha (Thr638)
IR:Immunogen Range:VL(p-T)PP
Clonality:Monoclonal
Isotype:IgG
Entrez Gene:5578
Swiss Prot:P17252
Source:KLH conjugated synthesised phosphopeptide derived from human PKC alpha around the phosphorylation site of Thr638:VL(p-T)PP
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Protein Kinase c alpha (PKC alpha) is an 77 kDa member of the conventional group (cPKCs: sensitive to calcium, diacylglycerol, phosphatidylserine and phorbol esters) of the PKC family of serine/ threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival and transcriptional regulation. PKC alpha is an ubiquitously expressed PKC isozyme that has been implicated in the regulation of a broad range of cellular functions including proliferation, differentiation, development, migration, cell cell adhesion, cell extracellular matrix adhesion, and solute transport. The activation loop threonine (threonine 497 in PKC alpha) of conventional PKCs is phosphorylated by phosphoinositide dependent kinase 1 (PDK1). This phosphorylation is necessary for the autophosphorylation of threonine 638 in the carboxy terminus of PKC alpha, a step that is critical for regulating the rate of PKC alpha dephosphorylation and inactivation.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
IHC-P(1:50-1:500)
IHC-F(1:50-1:500)
Flow-Cyt(2ug/Test)
ICC(1:50)
IF(1:50-1:500)
Cross Reactive Species:Human
Mouse
Rat
Chicken
Pig
Cow
Horse
本產(chǎn)品僅供科研使用。不能用于人和動物治療等其它臨床診斷使用！
關(guān)鍵字： Thr638;PKC A; PICK 1;PRKACA;PRKC A;
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