Product Name：Polymyxin B nonapeptide
CAS No.：86408-36-8；2220175-42-6
Synonyms：PMBN；sPMBN；陽離子環(huán)肽；多粘菌素B九肽
Catalog No.：218P082
Brand：HongTide（上海鴻肽生物）
Description：Polymyxin B nonapeptide是一條由9個氨基酸組成的陽離子環(huán)肽，序列中含有5個Dab，其主要官能團是氨基，是一種來自抗生素多粘菌素B的多肽。Polymyxin B nonapeptide能與革蘭氏陰性細菌的外膜相互作用，從而通過促進疏水性擴散來增加膜的滲透性。Polymyxin B nonapeptide毒性較小，缺乏殺菌活性，并保持其通過透化革蘭氏陰性菌的外膜使革蘭氏陰性菌對幾種抗生素敏感的能力。
Polymyxin B nonapeptide is a cationic cyclic peptide composed of 9 amino acids, containing 5 Dabs in its sequence, and its main functional group is amino. It is a peptide derived from antibiotic polymyxin B. Polymyxin B nonapeptide can interact with the outer membrane of gram negative bacteria, thereby increasing membrane permeability by promoting hydrophobic diffusion. Polymyxin B nonapeptide is less toxic, lacks bactericidal activity, and maintains its ability to sensitize gram-negative bacteria to several antibiotics by penetrating the outer membrane of gram-negative bacteria.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | T-Dab-Dab-Dab-d-F-L-Dab-Dab-T(Lactam: Dab3-Thr9) |
Sequence(3-letter code) | H-Thr-Dab-Dab-Dab-d-Phe-Leu-Dab-Dab-Thr-OH(Lactam: Dab3-Thr9) |
Peptide Structure | 
|
Molecular Formula | C43H74N14O11 |
Molecular Weight | 963.13 |
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上海鴻肽生物科技有限公司（簡稱：鴻肽生物）是一家以多肽以及多肽上下游產品研發(fā)、生產、銷售以及技術轉讓為主要業(yè) 務科技公司。公司現有產品涵蓋：定制多肽、目錄多肽、氨基酸衍生物、小分子化合物；公司自成立以來，秉持“用質量作船， 以服務為帆，為科研服務”的企業(yè)理念，為國內外眾多科研工作者提供了優(yōu)質的服務及產品。