Product Name：Polymyxin B nonapeptide
CAS No.：86408-36-8；2220175-42-6
Synonyms：PMBN；sPMBN；陽(yáng)離子環(huán)肽；多粘菌素B九肽
Catalog No.：218P082
Brand：HongTide（上海鴻肽生物）
Description：Polymyxin B nonapeptide是一條由9個(gè)氨基酸組成的陽(yáng)離子環(huán)肽，序列中含有5個(gè)Dab，其主要官能團(tuán)是氨基，是一種來(lái)自抗生素多粘菌素B的多肽。Polymyxin B nonapeptide能與革蘭氏陰性細(xì)菌的外膜相互作用，從而通過(guò)促進(jìn)疏水性擴(kuò)散來(lái)增加膜的滲透性。Polymyxin B nonapeptide毒性較小，缺乏殺菌活性，并保持其通過(guò)透化革蘭氏陰性菌的外膜使革蘭氏陰性菌對(duì)幾種抗生素敏感的能力。
Polymyxin B nonapeptide is a cationic cyclic peptide composed of 9 amino acids, containing 5 Dabs in its sequence, and its main functional group is amino. It is a peptide derived from antibiotic polymyxin B. Polymyxin B nonapeptide can interact with the outer membrane of gram negative bacteria, thereby increasing membrane permeability by promoting hydrophobic diffusion. Polymyxin B nonapeptide is less toxic, lacks bactericidal activity, and maintains its ability to sensitize gram-negative bacteria to several antibiotics by penetrating the outer membrane of gram-negative bacteria.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | T-Dab-Dab-Dab-d-F-L-Dab-Dab-T(Lactam: Dab3-Thr9) |
Sequence(3-letter code) | H-Thr-Dab-Dab-Dab-d-Phe-Leu-Dab-Dab-Thr-OH(Lactam: Dab3-Thr9) |
Peptide Structure | 
|
Molecular Formula | C43H74N14O11 |
Molecular Weight | 963.13 |
訂購(gòu)聯(lián)系方式：
上海鴻肽生物科技有限公司
手機(jī)： +86-18018095145 （同微信號(hào)）
QQ: 3259098395
郵箱：sales1@hongtide.com
關(guān)鍵字： 86408-36-8;2220175-42-6;陽(yáng)離子環(huán)肽;Polymyxin B nonapept;多肽;
上海鴻肽生物科技有限公司（簡(jiǎn)稱(chēng)：鴻肽生物）是一家以多肽以及多肽上下游產(chǎn)品研發(fā)、生產(chǎn)、銷(xiāo)售以及技術(shù)轉(zhuǎn)讓為主要業(yè) 務(wù)科技公司。公司現(xiàn)有產(chǎn)品涵蓋：定制多肽、目錄多肽、氨基酸衍生物、小分子化合物；公司自成立以來(lái)，秉持“用質(zhì)量作船， 以服務(wù)為帆，為科研服務(wù)”的企業(yè)理念，為國(guó)內(nèi)外眾多科研工作者提供了優(yōu)質(zhì)的服務(wù)及產(chǎn)品。