價格 | ¥2816.13 |
包裝 | 10 MG |
最小起訂量 | 1MG |
發(fā)貨地 | 上海 |
更新日期 | 2023-10-27 |
中文名稱:Haspin Kinase Inhibitor, CHR-6494 Calbiochem | CAS:1333377-65-3 |
品牌: Sigma |
產(chǎn)品編號 | 372040 |
品牌 | Sigma |
形式 | solid |
顏色 | off-white |
測定 | ≥98% (HPLC) |
警告 | Toxicity: Standard Handling (A) |
運輸 | ambient |
分子量 | 292.34 |
溶解性 | DMSO: 25?mg/mL |
儲存條件 | OK to freeze protect from light |
儲存溫度 | ?20°C |
其他說明 | Huertas, D., et al. 2012. Oncogene31, 1408. |
質(zhì)量水平 | 100 |
別名
Haspin Kinase Inhibitor, CHR-6494 - CAS 1333377-65-3 - Calbiochem,Indazolyl-propylimidazopyridazin-amine, 3-(1H-Indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine, Haploid Germ Cell-Specific Nuclear Protein Kinase Inhibitor, CHR-6494
一般描述
A cell-permeable indazolylimidazopyridazinamine compound that acts as a potent and reversible inhibitor of histone kinase haspin activity (IC50 = 2 nM) with moderate selectivity over TrkA, GSK-3β, PIM1, Cdk1/B and Cdk2/A (% inhibition at 100 nM = 58, 48, 36, 34 and 33, respectively) among a panel of 27-kinases. Shown to block pH3-Thr3, with no effect on pH3-Ser10 and pH3-Ser28, cause mitotic catastrophe, upregulate BUB1 and cyclin B1 levels, and potently induce apoptosis (IC50 = 473, 500 and 752 nM in HeLa, HCT-116 and MDA-MB-231 cells, respectively). Further, efficiently blocks bFGF-induced sprouting vessel by 70% at 1 μM (chicken embryo aortic arch ring assay) and suppresses tumor growth in HCT-116 xenografted mouse model (50 mg/kg, i.p.).
重懸
Following reconstitution, aliqout and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
成立日期 | 2005-12-27 (20年) | 注冊資本 | 600.0萬美元 |
員工人數(shù) | 100-500人 | 年營業(yè)額 | ¥ 1億以上 |
主營行業(yè) | 分析化學,材料化學,生物化工,化學試劑,催化劑 | 經(jīng)營模式 | 貿(mào)易,試劑,定制,服務(wù) |
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