產(chǎn)品屬性：
產(chǎn)品名稱 | 規(guī)格 | CAS號 | 型號 |
Falcarinol | 1mg 5mg 10mg 25mg | 21852-80-2 | EY-Y0164963 |
Cas No.21852-80-2
別名 N/A
化學(xué)名 1,9Z-heptadecadiene-4,6-diyn-3R-ol
分子式 C17H24O
分子量 244.4
溶解度 DMF: 20 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 20 mg/ml
儲存條件 Store at-20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
Falcarinol is a C17-polyacetylene produced by the Apiaceae family that has antimicrobial properties due to its inhibition of fatty acid biosynthesis. [1] [2] Falcarinol binds to the human recombinant cannabinoid (CB) receptors, CB1 and CB2, (Kis = 594 and 2,100 nM, respectively) in an [3H]anandamide displacement assay in HEK293 cells.[3] It differentially modulates synaptic and extrasynaptic GABAA receptors in a recombinant HEK293 system. [4] In vitro assays of ATPase activity demonstrate that falcarinol inhibits breast cancer resistance protein ATP-binding cassette sub-family G member 2 (ABCG2; IC50 = 79.3 μM), a drug efflux transporter and mediator of drug resistance. [5] Falcarinol (6.88 μg/g feed) also inhibits aberrant crypt foci by 26.6% in azoxymethane-induced rats. [6]
Reference:
[1]. Dawid, C., Dunemann, F., Schwab, W., et al. Bioactive C??-polyacetylenes in carrots (Daucus carota L.): Current knowledge and future perspectives. J. Agric. Food Chem. 63(42), 9211-9222 (2015).
[2]. Li, H., Cowie, A., Johnson, J.A., et al. Determining the mode of action of antimycobacterial C17 diyne natural products using expression profiling: Evidence for fatty acid biosynthesis inhibition. BMC Genomics 17(1), 621 (2016).
[3]. Leonti, M., Casu, L., Raduner, S., et al. Falcarinol is a covalent cannabinoid CB1 receptor antagonist and induces pro-allergic effects in skin. Biochem. Pharmacol. 79(12), 1815-1826 (2010).
[4]. Czyzewska, M.M., Chrobok, L., Kania, A., et al. Dietary acetylenic oxylipin falcarinol differentially modulates GABAA receptors. J. Nat. Prod. 77(12), 2671-2677 (2014).
[5]. Tan, K.W., Killeen, D.P., Li, Y., et al. Dietary polyacetylenes of the falcarinol type are inhibitors of breast cancer resistance protein (BCRP/ABCG2). Eur. J. Pharmacol. 723, 346-352 (2014).
[6]. Kobaek-Larsen, M., El-Houri, R.B., Christensen, L.P., et al. Dietary polyacetylenes, falcarinol and falcarindiol, isolated from carrots prevents the formation of neoplastic lesions in the colon of azoxymethane-induced rats. Food Funct. 8(3), 964-974 (2017).
關(guān)鍵字： 21852-80-2;C17H24O;Falcarinol;
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