中文名稱

雙唾液酸神經(jīng)節(jié)苷脂GD1a（NH4 +鹽）

英文名字

Disialoganglioside GD1a (NH4+ salt)

供應商

Matreya

產(chǎn)品貨號

1062-5

背景資料

Gangliosides1 are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis, and metastasis.2 The accumulation of gangliosides has been linked to several diseases including Tay-Sachs and Sandhoff disease. An autoimmune response against gangliosides can lead to Guillain-Barre syndrome. GD1a is one of the major brain gangliosides. It is a coreceptor of Toll-like receptor 2 signaling3 and it inhibits concanavalin A-induced 45Ca2 + uptake although it is not cytotoxic nor does it significantly alter the rate of Ca2 + efflux. Along with other gangliosides GD1a enhances tumor cell proliferation, invasion, and metastasis. It is a receptor for cholera toxin and contributes to the sodium channel functional variability within and between neuronal cells. GD1a causes a significant increase in the responsiveness of epidermal growth factor receptors, a condition that is often associated with the formation of tumors.4

產(chǎn)品描述

GD1a

產(chǎn)品形式

該雙唾液酸神經(jīng)節(jié)苷脂GD1a（NH4 +鹽）產(chǎn)品為固體形式

保存建議

對于本產(chǎn)品，我們推薦使用-20℃藍冰低溫進行運輸。在您收到貨物后，我們建議在-20℃溫度下冷凍保存，溶解使用說明請參考本品說明書。