中文名稱

INT-777

英文名字

INT-777

供應商

開曼生物

產(chǎn)品貨號

17678-500

產(chǎn)品報價

￥1601.6/500ug

產(chǎn)品說明書

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購買方式

銀行轉(zhuǎn)賬、電匯、支票、現(xiàn)金，在線支付寶及網(wǎng)銀支付，或直接與我們電話聯(lián)系400-6800-868

產(chǎn)品新聞

背景資料

TGR5 is a transmembrane G protein-coupled receptor that is activated by bile acid.{29321} INT-777 is a semisynthetic bile acid that acts as an agonist of TGR5 (EC50 = 0.82 μM).{17880,29490} It is active in vivo, stimulating the secretion of glucagon-like peptide-1 (GLP-1) in mice when given orally (30 mg/kg) after a glucose challenge, particularly when given with a dipeptidyl-peptidase-4 inhibitor.{29490} INT-777 increases energy expenditure and reduces hepatic steatosis and adiposity in mice subjected to diet-induced obesity.{29490} It also stimulates insulin secretion in pancreatic β cells, reduces inflammation and inhibits atherosclerosis in mice, and promotes chloride secretion through cystic fibrosis transmembrane conductance regulator (CFTR) in Calu-3 airway epithelial cells.{29487,29489,29486}

產(chǎn)品描述

An agonist of TGR5 (EC50 = 0.82 μM); stimulates the secretion of GLP-1 in mice when given orally (30 mg/kg) after a glucose challenge, particularly when given with a DPP4 inhibitor; increases energy expenditure and reduces hepatic steatosis and adiposity in mice subjected to diet-induced obesity

保存建議

建議您在收到開曼生物品牌的INT-777 (500 ug)產(chǎn)品后置于-20℃保存.

其他

開曼生物向全球科學工作者提供多研究領域的生化、免疫試劑和分析試劑盒，其產(chǎn)品被廣泛應用于腫瘤、氧化氮、神經(jīng)學、凋亡、氧化性損傷、內(nèi)分泌學等不同研究領域.開曼生物可提供用于檢測的特色試劑盒，如：類花生酸類物質(zhì)、游離的生物標志、環(huán)核苷、激素及氧化氮等；也提供多種高質(zhì)量試劑，包括：類花生酸類物質(zhì)、氧化氮試劑及許多相關脂質(zhì)、脂肪酸、酶和抗體.作為開曼生物在中國的區(qū)域總代理，艾美捷科技有限公司將為中國客戶提供最全面的開曼生物產(chǎn)品以及客戶訂制化服務.