英文名稱：
CCT245737
CAS號：
1489389-18-5
分子式：
C16H16F3N7O
分子量：
379.34
沸點
547.2±50.0 °C(Predicted)
密度
1.44±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)
8.56±0.40(Predicted)
In vitro: CCT245737 shows <50% inhibition at 10 μM for 85/121 kinases, representing a selectivity for CHK1 inhibition of >5000-fold over these enzymes. [1] CCT245737 enhanced gemcitabine antitumor activity to a greater degree than for higher doses of either agent alone, without increasing toxicity. In vivo: CCT2457374 shows an increase in plasma and tumoconcentrations between 3?100 mg/kg po.
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