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(+)-Bicuculline 比枯枯靈 CAS:485-49-4
發(fā)布日期:2017/3/15 13:25:40發(fā)布人:上海佰世凱化學(xué)科技有限公司

CAS:485-49-4

C10599

比枯枯靈

Product Name:(+)-Bicuculline

Synonyms:D-Bicuculline

Chemical Name:[R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one

Molecular Formula:C20H17NO6

Formula Weight:367.36

Purity:>99%

Appearance:Elongated plates from chloroform-menthanol or pale yellow crystalline powder

Solubility:Soluble to 5 mM in ethanol with gentle warming and to 100 mM in DMSO

Occurrence: Found in Dicentra cucullaria (L.) Bernh., Adlumia fungosa (Ait.) Greene, Fumariaceae, and several Corydalis species.

Biological Activity:
(+)-Bicuculline, a convulsant alkaloid, is the antagonist of GABA.

References:
[1]. Zahm DS, et al. Comparison of the locomotor-activating effects of bicuculline infusions into the preoptic area and ventral pallidum. Brain Struct Funct. 2014 Mar;219(2):511-26.
[2]. Johnston GA. Advantages of an antagonist: bicuculline and other GABA antagonists. Br J Pharmacol. 2013 May;169(2):328-36.
[3]. Graham AR Johnston. Advantages of an antagonist: bicuculline and other GABA antagonists. Br J Pharmacol. 2013 May; 169(2): 328–336.

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