Use of Tropicamide
Tropicamide is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist .Target: mAChRTropicamide is an antimuscarinic drug that produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied as eye drops. It is used to allow better examination of the lens, vitreous humor, and retina. Due to its relatively short duration of effect (4-8 hours), it is typically used during eye examinations such as the dilated fundus examination, but it may also be used before or after eye surgery. Cycloplegic drops are often also used to treat anterior uveitis, decreasing risk of posterior synechiae and decreasing inflammation in the anterior chamber of the eye [1-3].
Tropicamide Biological Activity
Description |
Tropicamide is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist .Target: mAChRTropicamide is an antimuscarinic drug that produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied as eye drops. It is used to allow better examination of the lens, vitreous humor, and retina. Due to its relatively short duration of effect (4-8 hours), it is typically used during eye examinations such as the dilated fundus examination, but it may also be used before or after eye surgery. Cycloplegic drops are often also used to treat anterior uveitis, decreasing risk of posterior synechiae and decreasing inflammation in the anterior chamber of the eye [1-3]. |
Related Catalog |
Signaling Pathways >> GPCR/G Protein >> mAChR
Signaling Pathways >> Neuronal Signaling >> mAChR
Research Areas >> Neurological Disease
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References |
[1]. Lazareno, S., N.J. Buckley, and F.F. Roberts, Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart, and NG108-15 cells. Mol Pharmacol, 1990. 38(6): p. 805-15.
[2]. Hernandez, M., et al., Different muscarinic receptor subtypes mediating the phasic activity and basal tone of pig isolated intravesical ureter. Br J Pharmacol, 1993. 110(4): p. 1413-20.
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Chemical & Physical Properties
Density |
1.2±0.1 g/cm3 |
Boiling Point |
492.8±45.0 °C at 760 mmHg |
Melting Point |
98 °C |
Molecular Formula |
C17H20N2O2 |
Molecular Weight |
284.353 |
Flash Point |
251.8±28.7 °C |
Exact Mass |
284.152466 |
PSA |
53.43000 |
LogP |
1.15 |
Vapour Pressure |
0.0±1.3 mmHg at 25°C |
Index of Refraction |
1.586 |
Storage condition |
2-8°C |
Water Solubility |
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 4.3 mg/mL
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Safety Information
Symbol |
GHS07 |
Signal Word |
Warning |
Hazard Statements |
H302 + H312 + H332-H315-H317-H319-H335 |
Precautionary Statements |
P261-P280-P301 + P312 + P330-P305 + P351 + P338 |
Hazard Codes |
Xn:Harmful |
Risk Phrases |
R20/21/22;R36/37/38;R42/43 |
Safety Phrases |
S22-S26-S36 |
RIDADR |
NONH for all modes of transport |
WGK Germany |
3 |
RTECS |
CY1487860 |
HS Code |
2933399090 |
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