Tucidinostat NEW
| Price | $58 | $92 | $171 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-06 |
Product Details
| Product Name: Tucidinostat | CAS No.: 1616493-44-7 |
| Purity: 98.76% | Supply Ability: 10g |
| Release date: 2024/11/06 |
Product Introduction
Bioactivity
| 名稱 | Tucidinostat |
| 描述 | Tucidinostat (Chidamide) is an effective and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8/11 (IC50: 733/432 nM), and shows no effect on HDAC4/5/6/7/9. |
| 體外活性 | Tucidinostat shows potent antitumor activity and inhibits several human-derived tumour cell lines, such as HL-60, U2OS, LNCaP with GI50s of 0.4 ± 0.1, 2.0 ± 0.6, and 4.0 ± 1.2 μM, respectively. In addition, Tucidinostat shows less toxic to normal cells from human fetal kidney (CCC-HEK) and liver (CCCHEL)[1]. |
| 體內(nèi)活性 | Tucidinostat, administered orally at doses ranging from 12.5 to 50 mg/kg, effectively and dose-dependently decreases tumor size and weight in mice afflicted with various carcinomas including HCT-8 colorectal, A549 lung, BEL-7402 liver, and MCF-7 breast, without any significant loss in body weight[1]. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : Insoluble 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 6 mg/mL (15.37 mM), Suspension. Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. DMSO : 60 mg/mL (153.68 mM) Ethanol : 1 mg/mL |
| 關(guān)鍵字 | HDAC | HBI 8000 | CS055 | Histone deacetylases | Tucidinostat | Inhibitor | inhibit | HBI8000 | CS-055 |
| 相關(guān)產(chǎn)品 | Sodium 4-phenylbutyrate | Curcumin |
| 相關(guān)庫 | 抗癌臨床化合物庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | 抗癌上市藥物庫 | 抗衰老化合物庫 | 抗癌藥物庫 | 抗癌活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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