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Postion:Product Catalog >SDZ 224-015
SDZ 224-015
  • SDZ 224-015

SDZ 224-015 NEW

Price $149
Package 1mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: SDZ 224-015 CAS No.: 161511-45-1
Purity: 95.49% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameSDZ 224-015
DescriptionSDZ 224-015 is an orally active inhibitor of interleukin-1β (IL-1β) converting enzyme and caspase-1, exhibiting anti-COVID-19 and anti-inflammatory activity, and reducing carrageenan gum-induced paw edema in rats.
In vitroSDZ 224-015 dose-dependently inhibited the release of IL-1β from the human monocytic cell line THP-1, with an IC50 of 0.24 μM, without affecting the release of IL-6, TNF-α, or lactate dehydrogenase[2].
In vivoSDZ 224-015 (0.3-300 micrograms kg-1) potently reduced carrageenin-induced paw oedema, with an oral ED50 of approximately 25 micrograms kg-1. SDZ 224-015 (0.2-5 mg kg-1, p.o.) displayed analgesic activity in the Randall-Selitto yeast-inflamed paw pressure test, significant at a dose of 1 mg kg-1, p.o[2].
Storagekeep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 80 mg/mL (122.60 mM), Sonication is recommended.
KeywordsSDZ 224-015 | SDZ 224 015
Inhibitors RelatedInosine pranobex | L-Arginine | Diallyl disulfide

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Address: 36?Washington?Street, Wellesley?Hills
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