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Postion:Product Catalog >MD-224
MD-224
  • MD-224

MD-224 NEW

Price $64 $155 $289
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: MD-224 CAS No.: 2136247-12-4
Purity: 99.07% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameMD-224
DescriptionMD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.
In vitroMD-224 effectively induces rapid degradation of MDM2 at concentrations <1 nM in human leukemia cells. It achieves an IC50 value of 1.5 nM in inhibition of growth of RS4;11 cells and also low nanomolar IC50 values in a panel of leukemia cell lines.
In vivoMD-224 achieves complete and durable tumor regression in vivo in the RS4;11 xenograft tumor model in mice at well-tolerated dose schedules.
Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 150 mg/mL (168.58 mM), Sonication is recommended.
Keywordsinhibit | PROTAC | Ubiquitin activating enzyme | MD 224 | Ubiquitin ligase | Inhibitor | MD224 | MDM-2/p53 | cancer | E1 activating enzyme | Ubiquitin conjugating enzyme | E3 ligating enzyme | RS4;11 | E1/E2/E3 Enzyme | leukemia | PROTACs | E2 conjugating enzyme | MD-224
Inhibitors RelatedMilademetan | XI-006 | PYZD-4409 | Nutlin-3 | NAcM-OPT | ARV-471 | dBET6 | NSC232003 | NAE-IN-M22 | Indole-3-carbinol
Related Compound LibrariesBioactive Compound Library | Ubiquitination Compound Library | Hematonosis Compound Library | NO PAINS Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Preclinical Compound Library | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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