Product Details
| Product Name:
Quinoclamine |
CAS No.:
2797-51-5 |
| Purity:
99.28% |
Supply Ability:
10g |
| Release date:
2024/11/18 |
Product Introduction
Bioactivity
| 名稱 | Quinoclamine |
| 描述 | Quinoclamine is a naphthoquinone derivative and is an NF-κB inhibitor. |
| 體外活性 | Quinoclamine induces the differentiation of U-937 cells into macrophage-like cells. Quinoclamine inhibits NF-κB activities in HepG2 cells (IC50: 1.7 μM). Quinoclamine inhibits induced NF-κB activities in lung and breast cancer cell lines. Quinoclamine affects the expression levels of genes involved in cell cycle or apoptosis. Quinoclamine down-regulates the expressions of UDP glucuronosyltransferase genes involved in phase II drug metabolism. Quinoclamine (1-4 μM; 30 minutes ) inhibits endogenous NF-κB activity in HepG2 cells through the inhibition of IκB-α phosphorylation and p65 translocation [1][2]. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (240.84 mM), Sonication is recommended.
|
| 關(guān)鍵字 | Quinoclamine | Nuclear factor-κB | NF-κB | derivative | inhibit | Inhibitor | Nuclear factor-kappaB | naphthoquinone |
| 相關(guān)產(chǎn)品 | Glucosamine | Diallyl disulfide |
| 相關(guān)庫(kù) | 農(nóng)藥化合物庫(kù) | 經(jīng)典已知活性庫(kù) | 抑制劑庫(kù) | 抗前列腺癌化合物庫(kù) | 抗衰老化合物庫(kù) | 已知活性化合物庫(kù) | 抗癌活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$1.00/1KG |
VIP5Y
|
Career Henan Chemical Co
|
2020-01-29 |
United States