Decursinol angelate NEW
| Price | $43 | $68 | $149 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-18 |
Product Details
| Product Name: Decursinol angelate | CAS No.: 130848-06-5 |
| Purity: 99.93% | Supply Ability: 10g |
| Release date: 2024/11/18 |
Product Introduction
Bioactivity
| Name | Decursinol angelate |
| Description | Decursinol angelate has anti-tumor, anti-inflammatory, anti-oxidant, and hepatoprotective activities, it inhibits VEGF-induced angiogenesis via suppression of the VEGFR-2-signaling pathway; it also suppresses invasion and inflammatory activation of cancer cells through modulation of PI3K/AKT, ERK and NF-kappaB, its anti-inflammatory activity may contribute to its anti-cancer activity. |
| In vitro | Here, we show that treatment with these compounds improves wound healing by HaCaT human keratinocytes. Wound healing was increased by treatment with up to a threshold concentration of decursin, Decursinol angelate, a mixture of both, and a nano-emulsion of these compounds, but inhibited by treatment with higher concentrations. Immunoblotting and fluorescence imaging of cells expressing an epidermal growth factor receptor (EGFR) biosensor demonstrated that these compounds did not stimulate wound healing by inducing EGFR phosphorylation. Rather, transcriptional analysis revealed that decursin and Decursinol angelate improved wound healing by upregulating the expression of genes encoding extracellular matrix remodeling proteins, inflammatory cytokines, and growth factors. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 65 mg/mL (197.95 mM) |
| Keywords | Protein kinase C | Decursinol angelate | inhibit | Inhibitor | PKC |
| Inhibitors Related | TBHQ | Nintedanib | α-Vitamin E | Lidocaine | Sorafenib | Astragaloside IV | Lidocaine hydrochloride | Regorafenib | Anisomycin | Tauroursodeoxycholate | Pazopanib | Axitinib |
| Related Compound Libraries | 神經退行性疾病化合物庫 | 經典已知活性庫 | 疼痛相關化合物庫 | 膜蛋白靶向化合物庫 | 酪氨酸激酶分子庫 | 激酶抑制劑庫 | 天然產物庫 | 已知活性化合物庫 | 古代經典名方目錄分子庫 | TGF-β/Smad靶點化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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| $79.00/1mg |
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TargetMol Chemicals Inc.
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2024-11-11 | |
| $0.00/5mg |
Shanghai Standard Technology Co., Ltd.
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2020-05-06 | ||
| $1500.00/1g |
NanJing Spring & Autumn Biological Engineering CO., LTD.
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2019-06-27 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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