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Postion:Product Catalog >PFI-2 hydrochloride
PFI-2 hydrochloride
  • PFI-2 hydrochloride

PFI-2 hydrochloride NEW

Price $34 $47 $77
Package 1mg 2mg 5mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-07

Product Details

Product Name: PFI-2 hydrochloride CAS No.: 1627607-87-7
Purity: 99.91% Supply Ability: 10g
Release date: 2024/11/07

Product Introduction

Bioactivity

名稱PFI-2 hydrochloride
描述PFI-2 hydrochloride ((R)-PFI-2 hydrochloride) is a potent, highly selective, and cell-active inhibitor of the methyltransferase activity of SETD7 (IC50: 2 nM), 500 fold active than (S)-PFI-2.
體外活性(R)-PFI-2 is highly selective (>1,000-fold) for SETD7, over a panel of 18 other human protein methyltransferases and DNMT1, and was shown to be inactive against 134 additional ion channel, GPCR, and enzyme targets (<35% inhibition at 10 μM). (R)-PFI-2 binds to SETD7 only in the presence of SAM. PFI-766, a biotinylated variant of (R)-PFI-2 that retains the ability to bind and inhibit SETD7 (IC50 110 ± 26 nM in our in vitro enzymatic assay).
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 55 mg/mL (102.62 mM)
Ethanol : 10 mg/mL
關(guān)鍵字macrophage | chronic kidney disease | PFI 2 Hydrochloride | inhibit | Histone Methyltransferase | PFI-2 | Inhibitor | SET domain containing lysine methyltransferase 7 (SETD7) | PFI2 hydrochloride | inflammation | PFI2 | PFI2 Hydrochloride | PFI 2 hydrochloride | PFI 2 | PFI-2 Hydrochloride | renal fibrosis
相關(guān)產(chǎn)品BIX-01294 trihydrochloride | Tazemetostat | Piribedil | XY1 | UNC 0631 | GSK126 | MAK683 | EZM 2302 | EPZ015666 | AMI-1 free acid | MS37452 | MRTX-1719
相關(guān)庫高選擇性抑制劑庫 | 細胞重編程化合物庫 | 表型篩選靶點鑒定庫 | 經(jīng)典已知活性庫 | 染色質(zhì)修飾分子庫 | 抑制劑庫 | NO PAINS 化合物庫 | 干細胞分化化合物庫 | 抗衰老化合物庫 | 已知活性化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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