PFI-2 hydrochloride NEW
Price | $34 | $47 | $77 |
Package | 1mg | 2mg | 5mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-07 |
Product Details
Product Name: PFI-2 hydrochloride | CAS No.: 1627607-87-7 |
Purity: 99.91% | Supply Ability: 10g |
Release date: 2024/11/07 |
Product Introduction
Bioactivity
名稱 | PFI-2 hydrochloride |
描述 | PFI-2 hydrochloride ((R)-PFI-2 hydrochloride) is a potent, highly selective, and cell-active inhibitor of the methyltransferase activity of SETD7 (IC50: 2 nM), 500 fold active than (S)-PFI-2. |
體外活性 | (R)-PFI-2 is highly selective (>1,000-fold) for SETD7, over a panel of 18 other human protein methyltransferases and DNMT1, and was shown to be inactive against 134 additional ion channel, GPCR, and enzyme targets (<35% inhibition at 10 μM). (R)-PFI-2 binds to SETD7 only in the presence of SAM. PFI-766, a biotinylated variant of (R)-PFI-2 that retains the ability to bind and inhibit SETD7 (IC50 110 ± 26 nM in our in vitro enzymatic assay). |
存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 55 mg/mL (102.62 mM) Ethanol : 10 mg/mL |
關(guān)鍵字 | macrophage | chronic kidney disease | PFI 2 Hydrochloride | inhibit | Histone Methyltransferase | PFI-2 | Inhibitor | SET domain containing lysine methyltransferase 7 (SETD7) | PFI2 hydrochloride | inflammation | PFI2 | PFI2 Hydrochloride | PFI 2 hydrochloride | PFI 2 | PFI-2 Hydrochloride | renal fibrosis |
相關(guān)產(chǎn)品 | BIX-01294 trihydrochloride | Tazemetostat | Piribedil | XY1 | UNC 0631 | GSK126 | MAK683 | EZM 2302 | EPZ015666 | AMI-1 free acid | MS37452 | MRTX-1719 |
相關(guān)庫 | 高選擇性抑制劑庫 | 細胞重編程化合物庫 | 表型篩選靶點鑒定庫 | 經(jīng)典已知活性庫 | 染色質(zhì)修飾分子庫 | 抑制劑庫 | NO PAINS 化合物庫 | 干細胞分化化合物庫 | 抗衰老化合物庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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