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Postion:Product Catalog >Biochemical Engineering>Inhibitors>Epigenetics>Histone Methyltransferase Inhibitors>PFI-2
PFI-2
  • PFI-2

PFI-2 NEW

Price $83 $131 $448
Package 5mg 10mg 50mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: PFI-2 CAS No.: 1627676-59-8
Supply Ability: 10g Release date: 2024/11/19

Product Introduction

Bioactivity

NamePFI-2
DescriptionPFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.
In vivoIn the cellular environment, through direct interaction with SETD7, PFI-2 affects Yes-associated protein localization in Hippo pathway signaling and the putative phenotype Setd7 gene deletion. The inhibitory activity of (R)-PFI-2 on human SETD7 was 500-fold higher than that of its isomer, (S)-PFI-2.
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationEthanol : 66 mg/mL (132.12 mM), Heating is recommended.
DMSO : >10 mM
KeywordsInhibitor | inhibit | macrophage | chronic kidney disease | renal fibrosis | PFI-2 | inflammation | Histone Methyltransferase | SET domain containing lysine methyltransferase 7 (SETD7)
Inhibitors RelatedBIX-01294 trihydrochloride | Tazemetostat | Piribedil | XY1 | UNC 0631 | GSK126 | MAK683 | EZM 2302 | EPZ015666 | AMI-1 free acid | MS37452 | MRTX-1719

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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