nAChR agonist 1 NEW
Price | $86 | $178 | $273 |
Package | 1mg | 5mg | 10mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-18 |
Product Details
Product Name: nAChR agonist 1 | CAS No.: 1394371-75-5 |
Purity: 97.59% | Supply Ability: 10g |
Release date: 2024/11/18 |
Product Introduction
Bioactivity
Name | nAChR agonist 1 |
Description | nAChR agonist 1 (DUN71755) is a brain-permeable and orally efficacious positive allosteric α7 nicotinic acetylcholine receptor (α7 nAChR)modulator. |
In vivo | nAChR agonist 1(compound 28) is a novel PAM of α7 nicotinic acetylcholine receptor (α7 nAChR).?Compound 28 showed good in vitro potency, with pharmacokinetic profile across species with excellent brain penetration and residence time.?Compound 28 robustly reversed the cognitive deficits in episodic/working memory in both time-delay and scopolamine-induced amnesia paradigms in the novel object and social recognition tasks, at very low dose levels. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 120 mg/mL (285.76 mM), Sonication is recommended. |
Keywords | oral | Nicotinic acetylcholine receptors | neuroblastoma | nAChR agonist-1 | nAChR agonist1 | nAChR agonist 1 | nAChR | Inhibitor | inhibit | DUN-71755 | DUN 71755 | disease | deficits | cognitive | cells | brain-permeable | Alzheimer’s |
Inhibitors Related | Adiphenine hydrochloride | Nanofin | Forskolin | Pilocarpine Hydrochloride | (+)-Sparteine | Olanzapine | CLOZAPINE N-OXIDE | Pilocarpine nitrate | Ribavirin | Amitriptyline hydrochloride | Choline chloride | Propoxur |
Related Compound Libraries | 神經(jīng)退行性疾病化合物庫 | 經(jīng)典已知活性庫 | 疼痛相關(guān)化合物庫 | 神經(jīng)信號分子庫 | 抗阿爾茨海默癥化合物庫 | 膜蛋白靶向化合物庫 | 神經(jīng)遞質(zhì)受體化合物庫 | NO PAINS 化合物庫 | 口服活性化合物庫 | 已知活性化合物庫 | 離子通道庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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