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Wholesale Pharmaceutical Intermediates CAS 443-48-1 Metronidazole Used in Antibiotic

Metronidazole is a nitroimidazole antibiotic medication used particularly for anaerobic bacteria and protozoa.Target: Antibacterial; AntiparasiticMetronidazole is a nitroimidazole antibiotic medication used particularly for anaerobic bacteria and protozoa. Metronidazole is an antibiotic, amebicide, and antiprotozoal.[1] It is the drug of choice for first episodes of mild-to-moderate Clostridium difficile infection [2]. Metronidazole, taken up by diffusion, is selectively absorbed by anaerobic bacteria and sensitive protozoa. Once taken up by anaerobes, it is non-enzymatically reduced by reacting with reduced ferredoxin, which is generated by pyruvate oxido-reductase. Many of the reduced nitroso intermediates will form sulfinamides and thioether linkages with cysteine-bearing enzymes, thereby deactivating these critical enzymes. As many as 150 separate enzymes are affected.In addition or alternatively, the metronidazole metabolites are taken up into bacterial DNA, and form unstable molecules. This function only occurs when metronidazole is partially reduced, and because this reduction usually happens only in anaerobic cells, it has relatively little effect upon human cells or aerobic bacteria.

Usage 

1. Metronidazole has the function of  broad spectrum of anaerobic bacteria and peptides.
2. Metronizalole is mainly used for the prevention and treatment of infections caused by anaerobic bacteria, like respiratory tract; digestive tract; the infection of enterocoelia and pelvic cavity; skin and soft tissue; bone and joint infection; endocarditis, brain abscess, blood poisoning and meningitis caused by bacteroides fragilis.
3. Metronizalole is widely used in the prevention and treatment of oral anaerobic bacteria infection.
4. Metronidazole has strong antibacterial effect to most anaerobic bacteria, used in the treatment of amebiasis, trichomoniasis and anaerobic infections.

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