Lamotrigine NEW
| Price | $46 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-07 |
Product Details
| Product Name: Lamotrigine | CAS No.: 84057-84-1 |
| Purity: 99.91% | Supply Ability: 10g |
| Release date: 2024/11/07 |
Product Introduction
Bioactivity
| 名稱 | Lamotrigine |
| 描述 | Lamotrigine (BW430C) is an Anti-epileptic Agent and Mood Stabilizer. The physiologic effect of lamotrigine is by means of Decreased Central Nervous System Disorganized Electrical Activity. |
| 激酶實驗 | Whole Cell [3H]R1881 Binding Assay: Fibroblasts are grown to confluence in five or six 150 cm2 tissue culture flasks for routine assay. This usually requires 4-6 weeks from the time of the initial seeding of the cell line. All studies are performed between passages 3-20. Two days before assay, the medium is changed to one lacking fetal calf serum. This is repeated again 24 hours before assay. Competition assays are performed with 0.5-1.0 nM [3H]R1881 and increasing amounts of the nonradioactive compounds. Binding to low affinity sites is determined in the presence of 5 × 10-7 M R1881 and is subtracted from whole cell binding of [3H]R 1881 obtained in the absence of any inhibitor to assess binding to 5 high affinity site |
| 體外活性 | Lamotrigine is active in electrically induced EEG after-discharge tests, indicating its ability to counteract simple and complex partial seizures. It demonstrates antiepileptic effects in mice and rats, preventing hind-limb extension induced by both MES (maximal electroshock) and pentylenetetrazole. The peak effects of Lamotrigine occur 1 hour post-administration, with a duration exceeding 24 hours. Intravenous administration of Lamotrigine at doses greater than 5 mg/kg in rats results in a dose-dependent reduction in after-discharge duration. |
| 體內(nèi)活性 | In rat cortical brain tissues cultured with 10 mg/L veratridine, Lamotrigine inhibited the release of glutamate and aspartate (both with an ED50 of 5.38 mg/L) twice as effectively as it inhibited the release of GABA (ED50 of 11.2 mg/L), without affecting the basal release of glutamate. Lamotrigine stabilizes presynaptic neuronal membranes by blocking voltage-dependent sodium channels, thereby preventing the release of excitatory neurotransmitters, especially glutamate and aspartate. It does not induce phencyclidine (PCP)-like central nervous system effects, does not act through direct inhibition of NMDA receptors, and may avoid the adverse effects associated with NMDA blockade. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 18.33 mg/mL (71.59 mM) Ethanol : 2.6 mg/mL (10 mM) |
| 關(guān)鍵字 | Autophagy | Lennox-Gastaut syndrome | tonic-clonic seizure | Na+ channels | epilepsy | inhibit | seizure | Na channels | Lamotrigine | focal seizure | Inhibitor | Sodium Channel |
| 相關(guān)產(chǎn)品 | Hydroxychloroquine | Guanidine hydrochloride |
| 相關(guān)庫 | 疼痛相關(guān)化合物庫 | 經(jīng)典已知活性庫 | 抗癌臨床化合物庫 | 藥物功能重定位化合物庫 | 抗癌上市藥物庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 抗癌藥物庫 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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